Anti-inflammatory, antinociceptive and antioxidant activities of ethanolic extract of Solanum nigrum L. fruits

الملخص EN

Ethanolic maceration extract of Solanum nigrum L.

fruits belonging to solanaceae family was used.

Anti-inflammatory activity of the extract was examined using carrageenan induced paw edema and xylene induced ear edema in mice.

Antinociceptive activity was studied using the hot plate and writhing tests.

The study was carried out using doses of 100, 200 and 400 mg / kg orally.

The extract showed significant anti-inflammatory and antinociceptive activity at the dose of 400 mg / kg (P < 0.01) as compared to standard drug Diclofenac sodium (50 mg / kg).

Antioxidant and reducing power activities were evaluated using different concentration (100-400 μg / mL) of ethanol extract.

The extract had the most potent antioxidant effect toward linoleic acid model system, and strong reducing power ability.