Protective effects of Parinari curatellifolia flavonoids against acetaminophen-induced hepatic necrosis in rats
المؤلفون المشاركون
Olaleye, Mari Tolulope
Amobonye, Ayodeji Emmannuel
Komolafe, Kayode
Akinmoladun, Afolabi Clement
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 21، العدد 5 (30 نوفمبر/تشرين الثاني 2014)، ص ص. 486-492، 7ص.
الناشر
تاريخ النشر
2014-11-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Abstract In the present study, we investigated the hepatoprotective potential of Parinari curatellifolia Planch (Chrysobalanaceae) in experimental rats in order to ascertain the validity of folkloric claims of its effectiveness in the treatment of hepatic-related disorders.
Flavonoid extract of P.
curatellifolia seed, PCF (10-, 20- or 30 mg/kg body weight) or silymarin (25 mg/kg), dissolved in corn oil, was administered by gavage to experimental animals once daily for 14 consecutive days before liver damage was chemically induced through the administration of acetaminophen (2 g/kg p.o.) on the 14th day.
Hepatoprotection was assessed by analyzing liver homogenate and serum for markers of hepatotoxicity – alanine aminotransferase (ALT), aspartate aminotransferase (AST), cglutamyl transferase (GGT) and lactate dehydrogenase (LDH) activities as well as prothrombin time (PT).
Evaluation of biochemical indices of oxidative stress – level of lipid peroxides (LPO), activities of superoxide dismutase (SOD) and catalase, along with histological assessment of hepatic tissue sections were also carried out.
Results revealed that all doses of PCF significantly (P < 0.001) and dose dependently prevented acetaminophen-induced increase in serum activities of hepatic enzymes (ALT, AST, GGT, LDH) and PT.
Furthermore, PCF (10- and 20 mg/kg) significantly (P< 0.001) reduced lipid peroxidation in liver tissue and restored the activities of the antioxidant enzymes SOD and catalase toward normal levels.
Histopathology of the liver tissue showed that PCF mitigated the toxicant-induced hepatocellular necrosis, reduced inflammatory cell infiltration and enhanced hepatocyte regeneration.
The results indicated that P.
curatellifolia flavonoids demonstrated remarkable hepatoprotective activity in acute liver injury caused by acetaminophen.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Olaleye, Mari Tolulope& Amobonye, Ayodeji Emmannuel& Komolafe, Kayode& Akinmoladun, Afolabi Clement. 2014. Protective effects of Parinari curatellifolia flavonoids against acetaminophen-induced hepatic necrosis in rats. Saudi Journal of Biological Sciences،Vol. 21, no. 5, pp.486-492.
https://search.emarefa.net/detail/BIM-410025
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Olaleye, Mari Tolulope…[et al.]. Protective effects of Parinari curatellifolia flavonoids against acetaminophen-induced hepatic necrosis in rats. Saudi Journal of Biological Sciences Vol. 21, no. 5 (Nov. 2014), pp.486-492.
https://search.emarefa.net/detail/BIM-410025
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Olaleye, Mari Tolulope& Amobonye, Ayodeji Emmannuel& Komolafe, Kayode& Akinmoladun, Afolabi Clement. Protective effects of Parinari curatellifolia flavonoids against acetaminophen-induced hepatic necrosis in rats. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 5, pp.486-492.
https://search.emarefa.net/detail/BIM-410025
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 492
رقم السجل
BIM-410025
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر