Effect of ruta chalepensis l. methanol extract on hepatorenal lead toxicity in experimental rats

العناوين الأخرى

تأثير مستخلص الميثانول للفيجن على سمية الرصاص للكبد و الكلية في جرذان التجارب

مقدم أطروحة جامعية

al-gamati, Samirah Muhammad

مشرف أطروحة جامعية

Abu al-Basal, Maryam

أعضاء اللجنة

Abu Zaytun, Ahmad
al-Disi, Ahmad

الجامعة

جامعة آل البيت

الكلية

كلية العلوم

القسم الأكاديمي

قسم العلوم الحياتية

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2013

الملخص الإنجليزي

Methanol extract of Ruta chalepensis L.

aerial parts was investigated to assess its effect on heapatorenal lead toxicity in experimental rats.

After overnight fasting, rats were injected intraperitonealy with 0.5 ml of lead acetate at a dose of 35 mg/kg body weight for five consecutive days.

Animals were divided into four groups of ten rats each: normal control; untreated negative control and rats treated with 200 mg/kg or 400 mg/kg body weight of Ruta chalepensis extract.

Treatments were performed by intraperitoneal injection of 1ml of the extract once a day for 28 consecutive days.

Results showed significant differences between treated and control groups during the whole period of experiment.

This was demonstrated by improving body weight and level of serum total protein, decreasing levels of serum ALT, AST, total bilirubin, blood urea nitrogen and creatinin.

As well, histological analysis revealed marked reduction in inflammation and structural alterations of liver and kidney organs of Ruta chalepensis-treated rats.

That may be attributed to anti-inflammatory, anti-oxidant and regenerative capacity of the extract.

التخصصات الرئيسية

الأحياء

الموضوعات

عدد الصفحات

95

قائمة المحتويات

Table of contents.

Abstract.

[Chapter One] : Introduction.

[Chapter Two] : Objectives.

[Chapter Three] : Literature review.

[Chapter Four] : Materials and methods.

[Chapter Five] : Results.

[Chapter Six] : Discussion.

[Chapter Seven] : Conclusions.

[Chapter Eight] : Recommendations.

References.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

al-gamati, Samirah Muhammad. (2013). Effect of ruta chalepensis l. methanol extract on hepatorenal lead toxicity in experimental rats. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-416108

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

al-gamati, Samirah Muhammad. Effect of ruta chalepensis l. methanol extract on hepatorenal lead toxicity in experimental rats. (Master's theses Theses and Dissertations Master). Al albayt University. (2013).
https://search.emarefa.net/detail/BIM-416108

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

al-gamati, Samirah Muhammad. (2013). Effect of ruta chalepensis l. methanol extract on hepatorenal lead toxicity in experimental rats. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-416108

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-416108