Effect of ruta chalepensis l. methanol extract on hepatorenal lead toxicity in experimental rats

Other Title(s)

تأثير مستخلص الميثانول للفيجن على سمية الرصاص للكبد و الكلية في جرذان التجارب

Dissertant

al-gamati, Samirah Muhammad

Thesis advisor

Abu al-Basal, Maryam

Comitee Members

Abu Zaytun, Ahmad
al-Disi, Ahmad

University

Al albayt University

Faculty

Faculty of Sciences

Department

Department of Biological Sciences

University Country

Jordan

Degree

Master

Degree Date

2013

English Abstract

Methanol extract of Ruta chalepensis L.

aerial parts was investigated to assess its effect on heapatorenal lead toxicity in experimental rats.

After overnight fasting, rats were injected intraperitonealy with 0.5 ml of lead acetate at a dose of 35 mg/kg body weight for five consecutive days.

Animals were divided into four groups of ten rats each: normal control; untreated negative control and rats treated with 200 mg/kg or 400 mg/kg body weight of Ruta chalepensis extract.

Treatments were performed by intraperitoneal injection of 1ml of the extract once a day for 28 consecutive days.

Results showed significant differences between treated and control groups during the whole period of experiment.

This was demonstrated by improving body weight and level of serum total protein, decreasing levels of serum ALT, AST, total bilirubin, blood urea nitrogen and creatinin.

As well, histological analysis revealed marked reduction in inflammation and structural alterations of liver and kidney organs of Ruta chalepensis-treated rats.

That may be attributed to anti-inflammatory, anti-oxidant and regenerative capacity of the extract.

Main Subjects

Biology

Topics

• Alcoholic beverages
• Lead
• Toxicology

No. of Pages

95

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-416108