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Virulence gene profiles of multidrug-resistant pseudomonas aeruginosa isolated from Iranian hospital infections
المؤلفون المشاركون
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 10 (31 أكتوبر/تشرين الأول 2014)، ص ص. 1-10، 10ص.
الناشر
تاريخ النشر
2014-10-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : The most common hospital-acquired pathogen is Pseudomonas aeruginosa.
It is a multidrug resistant bacterium causing systemic infections.
Objectives : The present study was carried out in order to investigate the distribution of virulence factors and antibiotic resistance properties of Pseudomonas aeruginosa isolated from various types of hospital infections in Iran.
Patients and Methods : Two-hundred and seventeen human infection specimens were collected from Baqiyatallah and Payambaran hospitals in Tehran, Iran.
The clinical samples were cultured immediately and samples positive for P.
aeruginosa were analyzed for the presence of antibiotic resistance and bacterial virulence genes using PCR (polymerase chain reaction).
Antimicrobial susceptibility testing was performed using disk diffusion methodology with Müeller–Hinton agar.
Results : Fifty-eight out of 127 (45.66 %) male infection specimens and 44 out of 90 (48.88 %) female infection specimens harbored P.
aeruginosa.
Also, 65 % (in male specimens) and 21 % (in female specimens) of respiratory system infections were positive for P.
aeruginosa, which was a high rate.
The genes encoding exoenzyme S (67.64 %) and phospholipases C (45.09 %) were the most common virulence genes found among the strains.
The incidences of various β-lactams encoding genes, including blaTEM, blaSHV, blaOXA, blaCTX-M, blaDHA, and blaVEB were 94.11 %, 16.66 %, 15.68 %, 18.62 %, 21.56 %, and 17.64 %, respectively.
The most commonly detected fluoroquinolones encoding gene was gyrA (15.
68 %).
High resistance levels to penicillin (100 %), tetracycline (90.19 %), streptomycin (64.70 %), and erythromycin (43.13 %) were observed too.
Conclusions : Our findings should raise awareness about antibiotic resistance in hospitalized patients in Iran.
Clinicians should exercise caution in prescribing antibiotics, especially in cases of human infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fazeli, Nastaran& Mumtaz, Hasan. 2014. Virulence gene profiles of multidrug-resistant pseudomonas aeruginosa isolated from Iranian hospital infections. Iranian Red Crescent Medical Journal،Vol. 16, no. 10, pp.1-10.
https://search.emarefa.net/detail/BIM-416748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fazeli, Nastaran& Mumtaz, Hasan. Virulence gene profiles of multidrug-resistant pseudomonas aeruginosa isolated from Iranian hospital infections. Iranian Red Crescent Medical Journal Vol. 16, no. 10 (Oct. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-416748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fazeli, Nastaran& Mumtaz, Hasan. Virulence gene profiles of multidrug-resistant pseudomonas aeruginosa isolated from Iranian hospital infections. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 10, pp.1-10.
https://search.emarefa.net/detail/BIM-416748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 9-10
رقم السجل
BIM-416748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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