Antimicrobial mechanism of copper (II)‎ 1,10-phenanthroline and 2,2’-bipyridyl complex on bacterial and fungal pathogens

الملخص EN

Copper based metallo drugs were prepared and their antibacterial, antifungal, molecular mechanism of [Cu (SAla) Phen] ÆH2O and [Cu (SAla) bpy] ÆH2O complexes were investigated.

The [Cu (SAla) Phen] ÆH2O and [Cu (SAla) bpy] ÆH2O were derived from the Schiff base alanine salicylaldehyde.

[Cu (SAla) Phen] ÆH2O showed noteworthy antibacterial and antifungal activity than the [Cu (SAla) bpy] ÆH2O and ligand alanine, salicylaldehyde.

The [Cu (SAla) Phen] ÆH2O complex showed significant antibacterial activity against Salmonella typhi, Staphylococcus aureus, Salmonella paratyphi and the antifungal activity against Candida albicans and Cryptococcus neoformans in well diffusion assay.

The mode of action of copper (II) complex was analyzed byDNAcleavage activity and in silico molecular docking.

The present findings provide important insight into the molecular mechanism of copper (II) complexes in susceptible bacterial and fungal pathogens.

These results collectively support the use of [Cu (SAla) Phen] ÆH2O complex as a suitable drug to treat bacterial and fungal infections.