Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2’-bipyridyl complex on bacterial and fungal pathogens
Joint Authors
Chandramohan, G.
Panneerselvam, A.
Chandraleka, S.
Ramya, K.
Dhanasekaran, D.
Priyadharshini, A.
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 6 (31 Dec. 2014), pp.953-962, 10 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Copper based metallo drugs were prepared and their antibacterial, antifungal, molecular mechanism of [Cu (SAla) Phen] ÆH2O and [Cu (SAla) bpy] ÆH2O complexes were investigated.
The [Cu (SAla) Phen] ÆH2O and [Cu (SAla) bpy] ÆH2O were derived from the Schiff base alanine salicylaldehyde.
[Cu (SAla) Phen] ÆH2O showed noteworthy antibacterial and antifungal activity than the [Cu (SAla) bpy] ÆH2O and ligand alanine, salicylaldehyde.
The [Cu (SAla) Phen] ÆH2O complex showed significant antibacterial activity against Salmonella typhi, Staphylococcus aureus, Salmonella paratyphi and the antifungal activity against Candida albicans and Cryptococcus neoformans in well diffusion assay.
The mode of action of copper (II) complex was analyzed byDNAcleavage activity and in silico molecular docking.
The present findings provide important insight into the molecular mechanism of copper (II) complexes in susceptible bacterial and fungal pathogens.
These results collectively support the use of [Cu (SAla) Phen] ÆH2O complex as a suitable drug to treat bacterial and fungal infections.
American Psychological Association (APA)
Chandraleka, S.& Ramya, K.& Chandramohan, G.& Dhanasekaran, D.& Priyadharshini, A.& Panneerselvam, A.. 2014. Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2’-bipyridyl complex on bacterial and fungal pathogens. Journal of Saudi Chemical Society،Vol. 18, no. 6, pp.953-962.
https://search.emarefa.net/detail/BIM-427043
Modern Language Association (MLA)
Chandraleka, S.…[et al.]. Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2’-bipyridyl complex on bacterial and fungal pathogens. Journal of Saudi Chemical Society Vol. 18, no. 6 (2014), pp.953-962.
https://search.emarefa.net/detail/BIM-427043
American Medical Association (AMA)
Chandraleka, S.& Ramya, K.& Chandramohan, G.& Dhanasekaran, D.& Priyadharshini, A.& Panneerselvam, A.. Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2’-bipyridyl complex on bacterial and fungal pathogens. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 6, pp.953-962.
https://search.emarefa.net/detail/BIM-427043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 962
Record ID
BIM-427043
