![](/images/graphics-bg.png)
The association of coagulation factor v (leiden) and factor ii (prothrom-bin) mutations with stroke
المؤلفون المشاركون
Zargari, Peyman
Nabavi, Ariane Sadr
Azarpazhooh, Mahmoud Reza
Pirhoushiaran, Maryam
Qasimi, Muhammad Rida
Hami, Javad
Nezhad, Payam Sasan
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 11 (30 نوفمبر/تشرين الثاني 2014)، ص ص. 1-5، 5ص.
الناشر
تاريخ النشر
2014-11-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Epidemiological studies indicate that over the past forty years, the stroke incidence rates has increased.
Factors V and II mutations are established genetic-variant risk factors for venous thrombosis ; however, their contribution to stroke is a controversial issue.
Objectives : This study aimed to investigate the potential association of FV and FII mutations with stroke in an Iranian population.
Patients and Methods : The study population consisted of 153 patients of different stroke subtypes (except cryptogenic strokes), admitted to Ghaem Hospital, Mashhad, Iran.
The control group included 153 age- and sex-matched subjects without a history of cerebrovascular or neurologic diseases.
Mutations of FV and FII were determined by using a TaqMan SNP Genotyping technique.
The chi-square and Exact Fisher tests were used to analyze the baseline characteristics.
Results were as follows : The calculated P-value for sex and diabetes mellitus were 0.907 and 1.000, respectively.
The case and control groups were also matched in low density lipoprotein (P = 0.816), high density lipoprotein (P = 0.323), triglyceride (P = 0.846), and total cholesterol (P = 0.079).
Results : Analysis of the FV showed that none of the study subjects were AA homozygous for this mutation and only 6 heterozygous subjects were detected in the case and control groups.
Regarding FII variants, none of the study subjects were AG heterozygous and only 1 AA homozygous was detected in the control group.
Conclusions : The prevalence of both FV and FII variants are population based.
Iran is an ethnically diverse country.
Therefore, for a comprehensive analysis of a potential association of FV and / or FII mutations with stroke among Iranian population, epidemiological studies could be conducted among different ethnic groups.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pirhoushiaran, Maryam& Qasimi, Muhammad Rida& Hami, Javad& Zargari, Peyman& Nezhad, Payam Sasan& Azarpazhooh, Mahmoud Reza…[et al.]. 2014. The association of coagulation factor v (leiden) and factor ii (prothrom-bin) mutations with stroke. Iranian Red Crescent Medical Journal،Vol. 16, no. 11, pp.1-5.
https://search.emarefa.net/detail/BIM-428193
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zargari, Peyman…[et al.]. The association of coagulation factor v (leiden) and factor ii (prothrom-bin) mutations with stroke. Iranian Red Crescent Medical Journal Vol. 16, no. 11 (Nov. 2014), pp.1-5.
https://search.emarefa.net/detail/BIM-428193
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pirhoushiaran, Maryam& Qasimi, Muhammad Rida& Hami, Javad& Zargari, Peyman& Nezhad, Payam Sasan& Azarpazhooh, Mahmoud Reza…[et al.]. The association of coagulation factor v (leiden) and factor ii (prothrom-bin) mutations with stroke. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 11, pp.1-5.
https://search.emarefa.net/detail/BIM-428193
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4-5
رقم السجل
BIM-428193
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)