The association of coagulation factor v (leiden)‎ and factor ii (prothrom-bin)‎ mutations with stroke

Abstract EN

Background : Epidemiological studies indicate that over the past forty years, the stroke incidence rates has increased.

Factors V and II mutations are established genetic-variant risk factors for venous thrombosis ; however, their contribution to stroke is a controversial issue.

Objectives : This study aimed to investigate the potential association of FV and FII mutations with stroke in an Iranian population.

Patients and Methods : The study population consisted of 153 patients of different stroke subtypes (except cryptogenic strokes), admitted to Ghaem Hospital, Mashhad, Iran.

The control group included 153 age- and sex-matched subjects without a history of cerebrovascular or neurologic diseases.

Mutations of FV and FII were determined by using a TaqMan SNP Genotyping technique.

The chi-square and Exact Fisher tests were used to analyze the baseline characteristics.

Results were as follows : The calculated P-value for sex and diabetes mellitus were 0.907 and 1.000, respectively.

The case and control groups were also matched in low density lipoprotein (P = 0.816), high density lipoprotein (P = 0.323), triglyceride (P = 0.846), and total cholesterol (P = 0.079).

Results : Analysis of the FV showed that none of the study subjects were AA homozygous for this mutation and only 6 heterozygous subjects were detected in the case and control groups.

Regarding FII variants, none of the study subjects were AG heterozygous and only 1 AA homozygous was detected in the control group.

Conclusions : The prevalence of both FV and FII variants are population based.

Iran is an ethnically diverse country.

Therefore, for a comprehensive analysis of a potential association of FV and / or FII mutations with stroke among Iranian population, epidemiological studies could be conducted among different ethnic groups.