Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid

الملخص EN

The purpose of this study is to develop colon-specific drug delivery systems with pH-sensitive drug release properties.

The azo polyurethane were characterized, and the drug content of the azo polyurethane was determined.Their behaviour and hydrolytic degradation was studied in simulated gastric fluid (SGF, pH = 4) and simulated intestinal fluid (SIF, pH = 7.8).

All synthesized monomers and polymers were characterized by FTIR, 1H-NMR spectra.

The release of 5-ASA under physiological conditions (pH = 7.8 and pH = 4) was investigated at body temperature (37 ºC).

The release rate of 5-ASA increased with increasing pH (7.8 > 4).