Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid
Joint Authors
Matar, Muhammad A.
Kamal, Rafid Qays
Jawad, Sabirin F.
Source
Iraqi National Journal of Chemistry
Issue
Vol. 2014, Issue 55 (30 Sep. 2014), pp.275-300, 26 p.
Publisher
University of Babylon College of Sciences
Publication Date
2014-09-30
Country of Publication
Iraq
No. of Pages
26
Main Subjects
Abstract AR
إن الغرض من الدراسة هو تطوير الأنظمة الخاصة في إطلاق الأدوية ذات الصفات الحساسة للحامضية.
حيث تميزت مركبات الازو للبولي يوريثان في تحديد محتوى الدواء فيه.
و كذلك تم دراسة سلوك تحلله في السائل المعوي للمعدة عند , 4 = pH و 7.8 = pH.
تم استخدام تقنيات ال FTIR, H^-NMR في تشخيص المونوميرات و البوليمرات التي تم تخليقها.
حيث تم تحرير 5-ASA عند نفس الظروف الفسيولوجية أي عند 7.8 = pH , 4 = pH و درجة حرارة الجسم 37 °C.
أن معدل سرعة تحرر 5-ASA تزداد مع زيادة درجة القاعدية اي (4 < 7.8 = .(pH
Abstract EN
The purpose of this study is to develop colon-specific drug delivery systems with pH-sensitive drug release properties.
The azo polyurethane were characterized, and the drug content of the azo polyurethane was determined.Their behaviour and hydrolytic degradation was studied in simulated gastric fluid (SGF, pH = 4) and simulated intestinal fluid (SIF, pH = 7.8).
All synthesized monomers and polymers were characterized by FTIR, 1H-NMR spectra.
The release of 5-ASA under physiological conditions (pH = 7.8 and pH = 4) was investigated at body temperature (37 ºC).
The release rate of 5-ASA increased with increasing pH (7.8 > 4).
American Psychological Association (APA)
Matar, Muhammad A.& Kamal, Rafid Qays& Jawad, Sabirin F.. 2014. Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid. Iraqi National Journal of Chemistry،Vol. 2014, no. 55, pp.275-300.
https://search.emarefa.net/detail/BIM-431600
Modern Language Association (MLA)
Matar, Muhammad A.…[et al.]. Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid. Iraqi National Journal of Chemistry No. 55 (2014), pp.275-300.
https://search.emarefa.net/detail/BIM-431600
American Medical Association (AMA)
Matar, Muhammad A.& Kamal, Rafid Qays& Jawad, Sabirin F.. Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid. Iraqi National Journal of Chemistry. 2014. Vol. 2014, no. 55, pp.275-300.
https://search.emarefa.net/detail/BIM-431600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 300
Record ID
BIM-431600
