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Serum vitamin D and peripheral T-regulatory cells in systemic lupus erythematosus and their relation with disease activity
المؤلفون المشاركون
Habib, Rim A.
al-Kabariti, Raniya H.
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 41، العدد 4 (31 ديسمبر/كانون الأول 2014)، ص ص. 167-171، 5ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Systemic lupus erythematosus (SLE) patients have a decreased number of T-regulatory cells (Tregs) in peripheral blood.
Vitamin D deficiency is prevalent in SLE.
Immunomodulatory effects of vitamin D include the expansion of Tregs.
Objectives : The aim of this study was to assess the percentage of Tregs and vitamin D level in SLE and their relation with disease activity.
Patients and Methods : A total of 40 SLE patients underwent evaluation for disease activity using the SLE disease activity index and were tested for the percentage of peripheral Tregs using anti-CD4, anti-CD25, and anti-FOXP3 monoclonal antibodies.
Vitamin D was assessed using a commercially available 25-OH VitD-EIA kit.
The study also included 40 healthy individuals who served as controls.
Results : SLE patients had lower levels of vitamin D (22.3 ± 7.53) and Treg % (1.95 ± 0.18) in comparison with controls.
Patients with active disease had significantly lower levels of vitamin D.
However, there was no significant difference between patients with and those without disease activity as regards Tregs.
Correlation between vitamin D and various disease parameters showed negative correlation between vitamin D and each of disease activity, creatinine, and urinary protein (P < 0.05) and a positive correlation with C4 (P < 0.05).
Correlation between Tregs % and various disease parameters showed a significant negative correlation as regards anti-dsDNA (P < 0.05).
No correlation was detected between Tregs % and vitamin D.
Conclusion : There are decreased levels of vitamin D and Treg % in SLE.
Lower levels of vitamin D correlate with disease activity ; yet, no correlation between serum vitamin D and Treg % was detected.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Habib, Rim A.& al-Kabariti, Raniya H.. 2014. Serum vitamin D and peripheral T-regulatory cells in systemic lupus erythematosus and their relation with disease activity. Egyptian Rheumatology and Rehabilitation،Vol. 41, no. 4, pp.167-171.
https://search.emarefa.net/detail/BIM-435681
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Habib, Rim A.& al-Kabariti, Raniya H.. Serum vitamin D and peripheral T-regulatory cells in systemic lupus erythematosus and their relation with disease activity. Egyptian Rheumatology and Rehabilitation Vol. 41, no. 4 (2014), pp.167-171.
https://search.emarefa.net/detail/BIM-435681
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Habib, Rim A.& al-Kabariti, Raniya H.. Serum vitamin D and peripheral T-regulatory cells in systemic lupus erythematosus and their relation with disease activity. Egyptian Rheumatology and Rehabilitation. 2014. Vol. 41, no. 4, pp.167-171.
https://search.emarefa.net/detail/BIM-435681
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 171
رقم السجل
BIM-435681
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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