Serum vitamin D and peripheral T-regulatory cells in systemic lupus erythematosus and their relation with disease activity
Joint Authors
Habib, Rim A.
al-Kabariti, Raniya H.
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 41, Issue 4 (31 Dec. 2014), pp.167-171, 5 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Systemic lupus erythematosus (SLE) patients have a decreased number of T-regulatory cells (Tregs) in peripheral blood.
Vitamin D deficiency is prevalent in SLE.
Immunomodulatory effects of vitamin D include the expansion of Tregs.
Objectives : The aim of this study was to assess the percentage of Tregs and vitamin D level in SLE and their relation with disease activity.
Patients and Methods : A total of 40 SLE patients underwent evaluation for disease activity using the SLE disease activity index and were tested for the percentage of peripheral Tregs using anti-CD4, anti-CD25, and anti-FOXP3 monoclonal antibodies.
Vitamin D was assessed using a commercially available 25-OH VitD-EIA kit.
The study also included 40 healthy individuals who served as controls.
Results : SLE patients had lower levels of vitamin D (22.3 ± 7.53) and Treg % (1.95 ± 0.18) in comparison with controls.
Patients with active disease had significantly lower levels of vitamin D.
However, there was no significant difference between patients with and those without disease activity as regards Tregs.
Correlation between vitamin D and various disease parameters showed negative correlation between vitamin D and each of disease activity, creatinine, and urinary protein (P < 0.05) and a positive correlation with C4 (P < 0.05).
Correlation between Tregs % and various disease parameters showed a significant negative correlation as regards anti-dsDNA (P < 0.05).
No correlation was detected between Tregs % and vitamin D.
Conclusion : There are decreased levels of vitamin D and Treg % in SLE.
Lower levels of vitamin D correlate with disease activity ; yet, no correlation between serum vitamin D and Treg % was detected.
American Psychological Association (APA)
Habib, Rim A.& al-Kabariti, Raniya H.. 2014. Serum vitamin D and peripheral T-regulatory cells in systemic lupus erythematosus and their relation with disease activity. Egyptian Rheumatology and Rehabilitation،Vol. 41, no. 4, pp.167-171.
https://search.emarefa.net/detail/BIM-435681
Modern Language Association (MLA)
Habib, Rim A.& al-Kabariti, Raniya H.. Serum vitamin D and peripheral T-regulatory cells in systemic lupus erythematosus and their relation with disease activity. Egyptian Rheumatology and Rehabilitation Vol. 41, no. 4 (2014), pp.167-171.
https://search.emarefa.net/detail/BIM-435681
American Medical Association (AMA)
Habib, Rim A.& al-Kabariti, Raniya H.. Serum vitamin D and peripheral T-regulatory cells in systemic lupus erythematosus and their relation with disease activity. Egyptian Rheumatology and Rehabilitation. 2014. Vol. 41, no. 4, pp.167-171.
https://search.emarefa.net/detail/BIM-435681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 171
Record ID
BIM-435681