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Studies on the role of goat heart galectin-1 as an erythrocyte membrane perturbing agent
المؤلفون المشاركون
Kamal, Muhammad A.
Ashraf, Ghulam Md
Tabrez, Shams
Perveen, Asma
Zaydi, Sayyid Kashif
Bani, Nahid
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 22، العدد 1 (31 مارس/آذار 2015)، ص ص. 112-116، 5ص.
الناشر
تاريخ النشر
2015-03-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Galectins are b-galactoside binding lectins with a potential hemolytic role on erythrocyte membrane integrity and permeability.
In the present study, goat heart galectin-1 (GHG-1) was purified and investigated for its hemolytic actions on erythrocyte membrane.
When exposed to various saccharides, lactose and sucrose provided maximum protection against hemolysis, while glucose and galactose provided lesser protection against hemolysis.
GHG-1 agglutinated erythrocytes were found to be significantly hemolyzed in comparison with unagglutinated erythrocytes.
A concentration dependent rise in the hemolysis of trypsinized rabbit erythrocytes was observed in the presence of GHG-1.
Similarly, a temperature dependent gradual increase in percent hemolysis was observed in GHG-1 agglutinated erythrocytes as compared to negligible hemolysis in unagglutinated cells.
The hemolysis of GHG-1 treated erythrocytes showed a sharp rise with the increasing pH up to 7.5 which became constant till pH 9.5.
The extent of erythrocyte hemolysis increased with the increase in the incubation period, with maximum hemolysis after 5 h of incubation.
The results of this study establish the ability of galectins as a potential hemolytic agent of erythrocyte membrane, which in turn opens an interesting avenue in the field of proteomics and glycobiology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ashraf, Ghulam Md& Perveen, Asma& Zaydi, Sayyid Kashif& Tabrez, Shams& Kamal, Muhammad A.& Bani, Nahid. 2015. Studies on the role of goat heart galectin-1 as an erythrocyte membrane perturbing agent. Saudi Journal of Biological Sciences،Vol. 22, no. 1, pp.112-116.
https://search.emarefa.net/detail/BIM-437407
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ashraf, Ghulam Md…[et al.]. Studies on the role of goat heart galectin-1 as an erythrocyte membrane perturbing agent. Saudi Journal of Biological Sciences Vol. 22, no. 1 (2015), pp.112-116.
https://search.emarefa.net/detail/BIM-437407
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ashraf, Ghulam Md& Perveen, Asma& Zaydi, Sayyid Kashif& Tabrez, Shams& Kamal, Muhammad A.& Bani, Nahid. Studies on the role of goat heart galectin-1 as an erythrocyte membrane perturbing agent. Saudi Journal of Biological Sciences. 2015. Vol. 22, no. 1, pp.112-116.
https://search.emarefa.net/detail/BIM-437407
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 116
رقم السجل
BIM-437407
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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