Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Huang, Juan
Li, Mei
Zhang, Binglan
Liu, Lei
Wei, Yuquan
Ma, Xuelei
Li, Minmin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Many studies have shown that microRNAs (miRNAs) could play a potential role as prognostic biomarkers of tumors.
The aim of this study is to summarize the global predicting role of microRNA-210 (miR-210) for survival in patients with a variety of carcinomas.
Methods.
Relevant literature was identified using PubMed and the information in eligible studies has been extracted.
Then meta-analysis of hazard ratio (HR) was performed to evaluate the prognostic role of the miR-210 in different tumors.
Results.
This meta-analysis included 9 published studies dealing with various carcinomas.
For recurrence free survival or disease free survival (RFS/DFS), the combined hazard ratio (HR) and 95% confidence interval (95% CI) of higher miR-210 expression were 2.47 [1.36, 4.46], which could significantly predict poor survival in general carcinomas.
MicroRNA-210 was also a significant predictor for overall survival (OS), metastasis free survival or distant relapse free survival (MFS/DRFS), and disease specific survival (DSS).
Importantly, subgroup analysis suggested that higher expression of miR-210 correlated with worse RFS/DFS, OS, and MFS/DRFS, especially in breast cancer, which were 3.36 [2.30, 4.93], 3.29 [1.65, 6.58], and 2.85 [1.76, 4.62] separately.
Conclusion.
Our studies suggested that microRNA-210 could predict the outcome of patients with varieties of tumors, especially in breast cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Minmin& Ma, Xuelei& Li, Mei& Zhang, Binglan& Huang, Juan& Liu, Lei…[et al.]. 2014. Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-446845
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Minmin…[et al.]. Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis. Disease Markers No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-446845
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Minmin& Ma, Xuelei& Li, Mei& Zhang, Binglan& Huang, Juan& Liu, Lei…[et al.]. Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-446845
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446845
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر