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Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Huang, Juan
Li, Mei
Zhang, Binglan
Liu, Lei
Wei, Yuquan
Ma, Xuelei
Li, Minmin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Many studies have shown that microRNAs (miRNAs) could play a potential role as prognostic biomarkers of tumors.
The aim of this study is to summarize the global predicting role of microRNA-210 (miR-210) for survival in patients with a variety of carcinomas.
Methods.
Relevant literature was identified using PubMed and the information in eligible studies has been extracted.
Then meta-analysis of hazard ratio (HR) was performed to evaluate the prognostic role of the miR-210 in different tumors.
Results.
This meta-analysis included 9 published studies dealing with various carcinomas.
For recurrence free survival or disease free survival (RFS/DFS), the combined hazard ratio (HR) and 95% confidence interval (95% CI) of higher miR-210 expression were 2.47 [1.36, 4.46], which could significantly predict poor survival in general carcinomas.
MicroRNA-210 was also a significant predictor for overall survival (OS), metastasis free survival or distant relapse free survival (MFS/DRFS), and disease specific survival (DSS).
Importantly, subgroup analysis suggested that higher expression of miR-210 correlated with worse RFS/DFS, OS, and MFS/DRFS, especially in breast cancer, which were 3.36 [2.30, 4.93], 3.29 [1.65, 6.58], and 2.85 [1.76, 4.62] separately.
Conclusion.
Our studies suggested that microRNA-210 could predict the outcome of patients with varieties of tumors, especially in breast cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Minmin& Ma, Xuelei& Li, Mei& Zhang, Binglan& Huang, Juan& Liu, Lei…[et al.]. 2014. Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-446845
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Minmin…[et al.]. Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis. Disease Markers No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-446845
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Minmin& Ma, Xuelei& Li, Mei& Zhang, Binglan& Huang, Juan& Liu, Lei…[et al.]. Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-446845
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446845
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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