Prognostic Role of MicroRNA-210 in Various Carcinomas : A Systematic Review and Meta-Analysis

Abstract EN

Objective.

Many studies have shown that microRNAs (miRNAs) could play a potential role as prognostic biomarkers of tumors.

The aim of this study is to summarize the global predicting role of microRNA-210 (miR-210) for survival in patients with a variety of carcinomas.

Methods.

Relevant literature was identified using PubMed and the information in eligible studies has been extracted.

Then meta-analysis of hazard ratio (HR) was performed to evaluate the prognostic role of the miR-210 in different tumors.

Results.

This meta-analysis included 9 published studies dealing with various carcinomas.

For recurrence free survival or disease free survival (RFS/DFS), the combined hazard ratio (HR) and 95% confidence interval (95% CI) of higher miR-210 expression were 2.47 [1.36, 4.46], which could significantly predict poor survival in general carcinomas.

MicroRNA-210 was also a significant predictor for overall survival (OS), metastasis free survival or distant relapse free survival (MFS/DRFS), and disease specific survival (DSS).

Importantly, subgroup analysis suggested that higher expression of miR-210 correlated with worse RFS/DFS, OS, and MFS/DRFS, especially in breast cancer, which were 3.36 [2.30, 4.93], 3.29 [1.65, 6.58], and 2.85 [1.76, 4.62] separately.

Conclusion.

Our studies suggested that microRNA-210 could predict the outcome of patients with varieties of tumors, especially in breast cancers.