Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types
المؤلفون المشاركون
Park, Byung L.
Jeong, Sangkyun
Shin, Hyoung D.
Koo, Imhoi
Kim, Kil S.
Choi, Sun M.
Kim, Jong Yeol
Cha, Seongwon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Sasang constitutional medicine (SCM), a Korean tailored medicine, categorizes human beings into four types through states of physiological imbalances and responsiveness to herbal medicine.
One SCM type susceptible to obesity seems sensitive to energy intake due to an imbalance toward preserving energy.
Common variants of fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes have been associated with increased body mass index (BMI) by affecting energy intake.
Here, we statistically examined the association of FTO and MC4R polymorphisms with BMI in two populations with 1370 Koreans before and after SCM typing, and with the lowering of BMI in 538 individuals who underwent a 1-month lifestyle intervention.
The increased BMI replicated the association with FTO haplotypes (effect size ≃ 1.1 kg/m2) and MC4R variants (effect size ≃ 0.64 kg/m2).
After the lifestyle intervention, the carriers of the haplotype represented by the minor allele of rs1075440 had a tendency to lose more waist-to-hip ratio (0.76%) than non-carriers.
The constitutional discrepancy for the accumulation of body mass by the effects of FTO and/or MC4R variants seemed to reflect the physique differences shown in each group of SCM constitutional types.
In conclusion, FTO and MC4R polymorphisms appear to play an important role in weight gain, while only FTO variants play a role in weight loss after lifestyle intervention.
Different trends were observed among individuals of SCM types, especially for weight gain.
Therefore, classification of individuals based on physiological imbalance would offer a good genetic stratification system in assessing the effects of obesity genes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cha, Seongwon& Koo, Imhoi& Park, Byung L.& Jeong, Sangkyun& Choi, Sun M.& Kim, Kil S.…[et al.]. 2011. Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-446869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cha, Seongwon…[et al.]. Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-446869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cha, Seongwon& Koo, Imhoi& Park, Byung L.& Jeong, Sangkyun& Choi, Sun M.& Kim, Kil S.…[et al.]. Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-446869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر