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Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types
Joint Authors
Park, Byung L.
Jeong, Sangkyun
Shin, Hyoung D.
Koo, Imhoi
Kim, Kil S.
Choi, Sun M.
Kim, Jong Yeol
Cha, Seongwon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sasang constitutional medicine (SCM), a Korean tailored medicine, categorizes human beings into four types through states of physiological imbalances and responsiveness to herbal medicine.
One SCM type susceptible to obesity seems sensitive to energy intake due to an imbalance toward preserving energy.
Common variants of fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes have been associated with increased body mass index (BMI) by affecting energy intake.
Here, we statistically examined the association of FTO and MC4R polymorphisms with BMI in two populations with 1370 Koreans before and after SCM typing, and with the lowering of BMI in 538 individuals who underwent a 1-month lifestyle intervention.
The increased BMI replicated the association with FTO haplotypes (effect size ≃ 1.1 kg/m2) and MC4R variants (effect size ≃ 0.64 kg/m2).
After the lifestyle intervention, the carriers of the haplotype represented by the minor allele of rs1075440 had a tendency to lose more waist-to-hip ratio (0.76%) than non-carriers.
The constitutional discrepancy for the accumulation of body mass by the effects of FTO and/or MC4R variants seemed to reflect the physique differences shown in each group of SCM constitutional types.
In conclusion, FTO and MC4R polymorphisms appear to play an important role in weight gain, while only FTO variants play a role in weight loss after lifestyle intervention.
Different trends were observed among individuals of SCM types, especially for weight gain.
Therefore, classification of individuals based on physiological imbalance would offer a good genetic stratification system in assessing the effects of obesity genes.
American Psychological Association (APA)
Cha, Seongwon& Koo, Imhoi& Park, Byung L.& Jeong, Sangkyun& Choi, Sun M.& Kim, Kil S.…[et al.]. 2011. Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-446869
Modern Language Association (MLA)
Cha, Seongwon…[et al.]. Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-446869
American Medical Association (AMA)
Cha, Seongwon& Koo, Imhoi& Park, Byung L.& Jeong, Sangkyun& Choi, Sun M.& Kim, Kil S.…[et al.]. Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-446869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446869