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Pentoxifylline Loaded Floating Microballoons : Design, Development and Characterization
المؤلفون المشاركون
Gulati, Neha
Malik, Prashant
Nagaich, Upendra
Malik, Raj Kaur
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
العلوم الاقتصادية والمالية وإدارة الأعمال
علم الصيدلة
الملخص EN
The floating microballoons have been utilized to obtain prolonged and uniform release in the stomach.
The objective of the present study involves design, development, and characterization of pentoxifylline loaded floating microballoons to prolong their gastric residence time.
Pentoxifylline (trisubstituted xanthine derivative) loaded microballoons were prepared by the solvent evaporation technique using different concentrations of polymers like HPMC K4M and ethyl cellulose (EC) in ethyl alcohol and dichloromethane organic solvent system.
Microballoons were characterized for their particle size, surface morphology, production yield, loading efficiency, buoyancy percentage, and in vitro drug release studies.
From the characterization it was observed that increases in amount of polymers (HPMC K4M and EC) led to increased particle size, loading efficiency, and buoyancy percentage, and retarded drug release.
The particle size, particle yield, loading efficiency, buoyancy percentage and in vitro drug release for optimized formulation (F3) were found to be 104.0±2.87 µm, 80.89±2.24%, 77.85±0.61%, 77.52±2.04%, and 82.21±1.29%, respectively.
The data was fitted to different kinetic models to illustrate its anomalous (non-Fickian) diffusion.
The in vitro result showed that formulations comprised of varying concentrations of ethyl cellulose in higher proportion exhibited much retarded drug release as compared to formulations comprised of higher proportion of varying concentrations of HPMC K4M.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malik, Prashant& Nagaich, Upendra& Malik, Raj Kaur& Gulati, Neha. 2013. Pentoxifylline Loaded Floating Microballoons : Design, Development and Characterization. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-446956
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malik, Prashant…[et al.]. Pentoxifylline Loaded Floating Microballoons : Design, Development and Characterization. Journal of Pharmaceutics No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-446956
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malik, Prashant& Nagaich, Upendra& Malik, Raj Kaur& Gulati, Neha. Pentoxifylline Loaded Floating Microballoons : Design, Development and Characterization. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-446956
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-446956
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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