Pentoxifylline Loaded Floating Microballoons : Design, Development and Characterization
Joint Authors
Gulati, Neha
Malik, Prashant
Nagaich, Upendra
Malik, Raj Kaur
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The floating microballoons have been utilized to obtain prolonged and uniform release in the stomach.
The objective of the present study involves design, development, and characterization of pentoxifylline loaded floating microballoons to prolong their gastric residence time.
Pentoxifylline (trisubstituted xanthine derivative) loaded microballoons were prepared by the solvent evaporation technique using different concentrations of polymers like HPMC K4M and ethyl cellulose (EC) in ethyl alcohol and dichloromethane organic solvent system.
Microballoons were characterized for their particle size, surface morphology, production yield, loading efficiency, buoyancy percentage, and in vitro drug release studies.
From the characterization it was observed that increases in amount of polymers (HPMC K4M and EC) led to increased particle size, loading efficiency, and buoyancy percentage, and retarded drug release.
The particle size, particle yield, loading efficiency, buoyancy percentage and in vitro drug release for optimized formulation (F3) were found to be 104.0±2.87 µm, 80.89±2.24%, 77.85±0.61%, 77.52±2.04%, and 82.21±1.29%, respectively.
The data was fitted to different kinetic models to illustrate its anomalous (non-Fickian) diffusion.
The in vitro result showed that formulations comprised of varying concentrations of ethyl cellulose in higher proportion exhibited much retarded drug release as compared to formulations comprised of higher proportion of varying concentrations of HPMC K4M.
American Psychological Association (APA)
Malik, Prashant& Nagaich, Upendra& Malik, Raj Kaur& Gulati, Neha. 2013. Pentoxifylline Loaded Floating Microballoons : Design, Development and Characterization. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-446956
Modern Language Association (MLA)
Malik, Prashant…[et al.]. Pentoxifylline Loaded Floating Microballoons : Design, Development and Characterization. Journal of Pharmaceutics No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-446956
American Medical Association (AMA)
Malik, Prashant& Nagaich, Upendra& Malik, Raj Kaur& Gulati, Neha. Pentoxifylline Loaded Floating Microballoons : Design, Development and Characterization. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-446956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-446956