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Simultaneous Analysis of Losartan Potassium, Amlodipine Besylate, and Hydrochlorothiazide in Bulk and in Tablets by High-Performance Thin Layer Chromatography with UV-Absorption Densitometry
المؤلفون المشاركون
Lakshmi, Sivasubramanian
Santhana Lakshmi, Karunanidhi
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-08
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
A Simple high-performance thin layer chromatography (HPTLC) method for separation and quantitative analysis of losartan potassium, amlodipine, and hydrochlorothiazide in bulk and in pharmaceutical formulations has been established and validated.
After extraction with methanol, sample and standard solutions were applied to silica gel plates and developed with chloroform : methanol : acetone : formic acid 7.5 : 1.3 : 0.5 : 0.03 (v/v/v/v) as mobile phase.
Zones were scanned densitometrically at 254 nm.
The Rf values of amlodipine besylate, hydrochlorothiazide, and losartan potassium were 0.35, 0.57, and 0.74, respectively.
Calibration plots were linear in the ranges 500–3000 ng per spot for losartan potassium, amlodipine and hydrochlorothiazide, the correlation coefficients, r, were 0.998, 0.998, and 0.999, respectively.
The suitability of this method for quantitative determination of these compounds was by validation in accordance with the requirements of pharmaceutical regulatory standards.
The method can be used for routine analysis of these drugs in bulk and in formulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santhana Lakshmi, Karunanidhi& Lakshmi, Sivasubramanian. 2012. Simultaneous Analysis of Losartan Potassium, Amlodipine Besylate, and Hydrochlorothiazide in Bulk and in Tablets by High-Performance Thin Layer Chromatography with UV-Absorption Densitometry. Journal of Analytical Methods in Chemistry،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-447055
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santhana Lakshmi, Karunanidhi& Lakshmi, Sivasubramanian. Simultaneous Analysis of Losartan Potassium, Amlodipine Besylate, and Hydrochlorothiazide in Bulk and in Tablets by High-Performance Thin Layer Chromatography with UV-Absorption Densitometry. Journal of Analytical Methods in Chemistry No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-447055
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santhana Lakshmi, Karunanidhi& Lakshmi, Sivasubramanian. Simultaneous Analysis of Losartan Potassium, Amlodipine Besylate, and Hydrochlorothiazide in Bulk and in Tablets by High-Performance Thin Layer Chromatography with UV-Absorption Densitometry. Journal of Analytical Methods in Chemistry. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-447055
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447055
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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