Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis

المؤلفون المشاركون

Seo, Minji
Chung, Gyung Tae
Park, Young Kil
Lee, Yeong Seon
Yoo, Jae-Il
Ryoo, Sungweon
Kim, Hyejin

المصدر

Tuberculosis Research and Treatment

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-03-28

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأمراض

الملخص EN

Many laboratories validate DST of the second-line drugs by BACTEC MGIT 960 system.

The objective of this study is to evaluate the critical concentration and perform DST for the 2nd line drugs.

We evaluated 193 clinical strains of M.

tuberculosis isolated from patients in South Korea.

Testing the critical concentration of six second-line drugs was performed by MGIT 960 and compared with L-J proportion method.

The critical concentration was determined to establish the most one that gave the difference between drug resistance and susceptibility in MGIT960 system.

Good agreement of the following concentrations was found: Concordance was 95% for 0.5 μg/mL of moxifloxacin; 93.6%, 1.0 μg/mL of levofloxacin; 97.5%, 2.5 μg/mL of kanamycin; 90.6%, 2.5 μg/mL of capreomycin; 86.2%, 5.0 μg/mL of ethionamide; and 90.8%, 2.0 μg/mL of ρ-aminosalicylic acid.

The critical concentrations of the four drugs, moxifloxacin, levofloxacin, kanamycin, and capreomycin, were concordant and reliable for testing 2nd line drug resistance.

Further study of ethionamide and ρ-aminosalicylic acid is required.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kim, Hyejin& Seo, Minji& Park, Young Kil& Yoo, Jae-Il& Lee, Yeong Seon& Chung, Gyung Tae…[et al.]. 2013. Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis. Tuberculosis Research and Treatment،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-447065

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kim, Hyejin…[et al.]. Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis. Tuberculosis Research and Treatment No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-447065

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kim, Hyejin& Seo, Minji& Park, Young Kil& Yoo, Jae-Il& Lee, Yeong Seon& Chung, Gyung Tae…[et al.]. Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis. Tuberculosis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-447065

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-447065