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Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis
Joint Authors
Seo, Minji
Chung, Gyung Tae
Park, Young Kil
Lee, Yeong Seon
Yoo, Jae-Il
Ryoo, Sungweon
Kim, Hyejin
Source
Tuberculosis Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Many laboratories validate DST of the second-line drugs by BACTEC MGIT 960 system.
The objective of this study is to evaluate the critical concentration and perform DST for the 2nd line drugs.
We evaluated 193 clinical strains of M.
tuberculosis isolated from patients in South Korea.
Testing the critical concentration of six second-line drugs was performed by MGIT 960 and compared with L-J proportion method.
The critical concentration was determined to establish the most one that gave the difference between drug resistance and susceptibility in MGIT960 system.
Good agreement of the following concentrations was found: Concordance was 95% for 0.5 μg/mL of moxifloxacin; 93.6%, 1.0 μg/mL of levofloxacin; 97.5%, 2.5 μg/mL of kanamycin; 90.6%, 2.5 μg/mL of capreomycin; 86.2%, 5.0 μg/mL of ethionamide; and 90.8%, 2.0 μg/mL of ρ-aminosalicylic acid.
The critical concentrations of the four drugs, moxifloxacin, levofloxacin, kanamycin, and capreomycin, were concordant and reliable for testing 2nd line drug resistance.
Further study of ethionamide and ρ-aminosalicylic acid is required.
American Psychological Association (APA)
Kim, Hyejin& Seo, Minji& Park, Young Kil& Yoo, Jae-Il& Lee, Yeong Seon& Chung, Gyung Tae…[et al.]. 2013. Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis. Tuberculosis Research and Treatment،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-447065
Modern Language Association (MLA)
Kim, Hyejin…[et al.]. Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis. Tuberculosis Research and Treatment No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-447065
American Medical Association (AMA)
Kim, Hyejin& Seo, Minji& Park, Young Kil& Yoo, Jae-Il& Lee, Yeong Seon& Chung, Gyung Tae…[et al.]. Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis. Tuberculosis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-447065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447065