Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes
المؤلفون المشاركون
Bankova, Vassya
Sforcin, José Maurício
Búfalo, Michelle Cristiane
Conti, Bruno José
Golim, Marjorie de Assis
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Propolis is a beehive product used in traditional medicine due to its biological properties.
It shows a complex chemical composition including phenolics, such as cinnamic acid (Ci).
The mechanisms of action of propolis have been the subject of research recently; however, the involvement of Ci on propolis activity was not investigated on immune cells.
Ci effects were evaluated on human monocytes, assessing the expression of Toll-like receptors (TLRs), HLA-DR, and CD80.
Cytokine production (TNF-α and IL-10) and the fungicidal activity of monocytes were evaluated as well.
Data showed that Ci downregulated TLR-2, HLA-DR, and CD80 and upregulated TLR-4 expression by human monocytes.
High concentrations of Ci inhibited both TNF-α and IL-10 production, whereas the same concentrations induced a higher fungicidal activity against Candida albicans.
TNF-α and IL-10 production was decreased by blocking TLR-4, while the fungicidal activity of monocytes was not affected by blocking TLRs.
These results suggest that Ci modulated antigen receptors, cytokine production, and the fungicidal activity of human monocytes depending on concentration, and TLR-4 may be involved in its mechanism of action.
Ci seemed to be partially involved in propolis activities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Conti, Bruno José& Búfalo, Michelle Cristiane& Golim, Marjorie de Assis& Bankova, Vassya& Sforcin, José Maurício. 2013. Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447205
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Conti, Bruno José…[et al.]. Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447205
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Conti, Bruno José& Búfalo, Michelle Cristiane& Golim, Marjorie de Assis& Bankova, Vassya& Sforcin, José Maurício. Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447205
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447205
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر