Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes
Joint Authors
Bankova, Vassya
Sforcin, José Maurício
Búfalo, Michelle Cristiane
Conti, Bruno José
Golim, Marjorie de Assis
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Propolis is a beehive product used in traditional medicine due to its biological properties.
It shows a complex chemical composition including phenolics, such as cinnamic acid (Ci).
The mechanisms of action of propolis have been the subject of research recently; however, the involvement of Ci on propolis activity was not investigated on immune cells.
Ci effects were evaluated on human monocytes, assessing the expression of Toll-like receptors (TLRs), HLA-DR, and CD80.
Cytokine production (TNF-α and IL-10) and the fungicidal activity of monocytes were evaluated as well.
Data showed that Ci downregulated TLR-2, HLA-DR, and CD80 and upregulated TLR-4 expression by human monocytes.
High concentrations of Ci inhibited both TNF-α and IL-10 production, whereas the same concentrations induced a higher fungicidal activity against Candida albicans.
TNF-α and IL-10 production was decreased by blocking TLR-4, while the fungicidal activity of monocytes was not affected by blocking TLRs.
These results suggest that Ci modulated antigen receptors, cytokine production, and the fungicidal activity of human monocytes depending on concentration, and TLR-4 may be involved in its mechanism of action.
Ci seemed to be partially involved in propolis activities.
American Psychological Association (APA)
Conti, Bruno José& Búfalo, Michelle Cristiane& Golim, Marjorie de Assis& Bankova, Vassya& Sforcin, José Maurício. 2013. Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447205
Modern Language Association (MLA)
Conti, Bruno José…[et al.]. Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-447205
American Medical Association (AMA)
Conti, Bruno José& Búfalo, Michelle Cristiane& Golim, Marjorie de Assis& Bankova, Vassya& Sforcin, José Maurício. Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-447205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447205