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A Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions
المؤلفون المشاركون
Park, Jea H.
Heffron, Fred
Sanford, James A.
Champion, Boyd L.
Brown, Roslyn N.
Smith, Richard D.
Deatherage, Brooke L.
Adkins, Joshua N.
المصدر
International Journal of Proteomics
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Towards developing a systems-level pathobiological understanding of Salmonella enterica, we performed a subcellular proteomic analysis of this pathogen grown under standard laboratory and phagosome-mimicking conditions in vitro.
Analysis of proteins from cytoplasmic, inner membrane, periplasmic, and outer membrane fractions yielded coverage of 25% of the theoretical proteome.
Confident subcellular location could be assigned to over 1000 proteins, with good agreement between experimentally observed location and predicted/known protein properties.
Comparison of protein location under the different environmental conditions provided insight into dynamic protein localization and possible moonlighting (multiple function) activities.
Notable examples of dynamic localization were the response regulators of two-component regulatory systems (e.g., ArcB and PhoQ).
The DNA-binding protein Dps that is generally regarded as cytoplasmic was significantly enriched in the outer membrane for all growth conditions examined, suggestive of moonlighting activities.
These observations imply the existence of unknown transport mechanisms and novel functions for a subset of Salmonella proteins.
Overall, this work provides a catalog of experimentally verified subcellular protein locations for Salmonella and a framework for further investigations using computational modeling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brown, Roslyn N.& Sanford, James A.& Park, Jea H.& Deatherage, Brooke L.& Champion, Boyd L.& Smith, Richard D.…[et al.]. 2012. A Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-447385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brown, Roslyn N.…[et al.]. A Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions. International Journal of Proteomics No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-447385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brown, Roslyn N.& Sanford, James A.& Park, Jea H.& Deatherage, Brooke L.& Champion, Boyd L.& Smith, Richard D.…[et al.]. A Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-447385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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