Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?
المؤلفون المشاركون
Ayatollahi, Hossein
Amel Jamedar, Saeed
Shaghayegh, Gohar
Memar, Bahram
Sheikhi, Maryam
Mohammadnia Avval, Maryam
Keramati, Mohammad Reza
Sadeghian, Mohammad Hadi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-26
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Human herpesvirus-8 (HHV-8) is associated with some human diseases including Kaposi’s sarcoma and also some B-cell lymphoproliferative disorders.
Few studies have highlighted the potential role of HHV-8 in the development of multiple myeloma (MM) which is known as a malignant proliferation of plasma cells derived from a single clone.
Aims.
The aim of this study was to find a relationship between HHV-8 and MM using polymerase chain reaction (PCR) method.
Materials and Methods.
This study was conducted on 30 formalin-fixed, paraffin-embedded (FFPE) bone marrow biopsies of multiple myeloma and 30 normal FFPE bone marrow biopsies.
After the sample preparation, Deoxyribonucleic acid (DNA) was extracted by nonheating procedure.
PCR for HHV-8 virus was carried out with commercial kit and the PCR products were visualized by gel electrophoresis.
Finally, the statistical analysis was performed.
Results.
HHV-8 virus was not detected by PCR from FFPE blocks of multiple myeloma samples, while only one of the controls showed DNA band of the corrected molecular weights.
Fisher’s exact test showed that no statistical differences were found between the two groups (P=0.999).
Conclusion.
Our report adds to the body of evidence that there is no association between HHV- 8 and MM against a major role of HHV-8 infection in the pathogenesis of clonal plasma cell proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sadeghian, Mohammad Hadi& Mohammadnia Avval, Maryam& Ayatollahi, Hossein& Keramati, Mohammad Reza& Memar, Bahram& Amel Jamedar, Saeed…[et al.]. 2013. Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?. Lymphoma،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-447403
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sadeghian, Mohammad Hadi…[et al.]. Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?. Lymphoma No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-447403
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sadeghian, Mohammad Hadi& Mohammadnia Avval, Maryam& Ayatollahi, Hossein& Keramati, Mohammad Reza& Memar, Bahram& Amel Jamedar, Saeed…[et al.]. Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?. Lymphoma. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-447403
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447403
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر