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Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?
Joint Authors
Ayatollahi, Hossein
Amel Jamedar, Saeed
Shaghayegh, Gohar
Memar, Bahram
Sheikhi, Maryam
Mohammadnia Avval, Maryam
Keramati, Mohammad Reza
Sadeghian, Mohammad Hadi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Human herpesvirus-8 (HHV-8) is associated with some human diseases including Kaposi’s sarcoma and also some B-cell lymphoproliferative disorders.
Few studies have highlighted the potential role of HHV-8 in the development of multiple myeloma (MM) which is known as a malignant proliferation of plasma cells derived from a single clone.
Aims.
The aim of this study was to find a relationship between HHV-8 and MM using polymerase chain reaction (PCR) method.
Materials and Methods.
This study was conducted on 30 formalin-fixed, paraffin-embedded (FFPE) bone marrow biopsies of multiple myeloma and 30 normal FFPE bone marrow biopsies.
After the sample preparation, Deoxyribonucleic acid (DNA) was extracted by nonheating procedure.
PCR for HHV-8 virus was carried out with commercial kit and the PCR products were visualized by gel electrophoresis.
Finally, the statistical analysis was performed.
Results.
HHV-8 virus was not detected by PCR from FFPE blocks of multiple myeloma samples, while only one of the controls showed DNA band of the corrected molecular weights.
Fisher’s exact test showed that no statistical differences were found between the two groups (P=0.999).
Conclusion.
Our report adds to the body of evidence that there is no association between HHV- 8 and MM against a major role of HHV-8 infection in the pathogenesis of clonal plasma cell proliferation.
American Psychological Association (APA)
Sadeghian, Mohammad Hadi& Mohammadnia Avval, Maryam& Ayatollahi, Hossein& Keramati, Mohammad Reza& Memar, Bahram& Amel Jamedar, Saeed…[et al.]. 2013. Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?. Lymphoma،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-447403
Modern Language Association (MLA)
Sadeghian, Mohammad Hadi…[et al.]. Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?. Lymphoma No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-447403
American Medical Association (AMA)
Sadeghian, Mohammad Hadi& Mohammadnia Avval, Maryam& Ayatollahi, Hossein& Keramati, Mohammad Reza& Memar, Bahram& Amel Jamedar, Saeed…[et al.]. Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?. Lymphoma. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-447403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447403