Inferring Biological Mechanisms by Data-Based Mathematical Modelling : Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case
المؤلف
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Biological functionality arises from the complex interactions of simple components.
Emerging behaviour is difficult to recognize with verbal models alone, and mathematical approaches are important.
Even few interacting components can give rise to a wide range of different responses, that is, sustained, transient, oscillatory, switch-like responses, depending on the values of the model parameters.
A quantitative comparison of model predictions and experiments is therefore important to distinguish between competing hypotheses and to judge whether a certain regulatory behaviour is at all possible and plausible given the observed type and strengths of interactions and the speed of reactions.
Here I will review a detailed model for the transcription factor σF, a regulator of cell differentiation during sporulation in Bacillus subtilis.
I will focus in particular on the type of conclusions that can be drawn from detailed, carefully validated models of biological signaling networks.
For most systems, such detailed experimental information is currently not available, but accumulating biochemical data through technical advances are likely to enable the detailed modelling of an increasing number of pathways.
A major challenge will be the linking of such detailed models and their integration into a multiscale framework to enable their analysis in a larger biological context.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iber, Dagmar. 2012. Inferring Biological Mechanisms by Data-Based Mathematical Modelling : Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case. Advances in Bioinformatics،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-447468
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iber, Dagmar. Inferring Biological Mechanisms by Data-Based Mathematical Modelling : Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case. Advances in Bioinformatics No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-447468
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iber, Dagmar. Inferring Biological Mechanisms by Data-Based Mathematical Modelling : Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case. Advances in Bioinformatics. 2012. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-447468
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447468
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر