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Inferring Biological Mechanisms by Data-Based Mathematical Modelling : Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Biological functionality arises from the complex interactions of simple components.
Emerging behaviour is difficult to recognize with verbal models alone, and mathematical approaches are important.
Even few interacting components can give rise to a wide range of different responses, that is, sustained, transient, oscillatory, switch-like responses, depending on the values of the model parameters.
A quantitative comparison of model predictions and experiments is therefore important to distinguish between competing hypotheses and to judge whether a certain regulatory behaviour is at all possible and plausible given the observed type and strengths of interactions and the speed of reactions.
Here I will review a detailed model for the transcription factor σF, a regulator of cell differentiation during sporulation in Bacillus subtilis.
I will focus in particular on the type of conclusions that can be drawn from detailed, carefully validated models of biological signaling networks.
For most systems, such detailed experimental information is currently not available, but accumulating biochemical data through technical advances are likely to enable the detailed modelling of an increasing number of pathways.
A major challenge will be the linking of such detailed models and their integration into a multiscale framework to enable their analysis in a larger biological context.
American Psychological Association (APA)
Iber, Dagmar. 2012. Inferring Biological Mechanisms by Data-Based Mathematical Modelling : Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case. Advances in Bioinformatics،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-447468
Modern Language Association (MLA)
Iber, Dagmar. Inferring Biological Mechanisms by Data-Based Mathematical Modelling : Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case. Advances in Bioinformatics No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-447468
American Medical Association (AMA)
Iber, Dagmar. Inferring Biological Mechanisms by Data-Based Mathematical Modelling : Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case. Advances in Bioinformatics. 2012. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-447468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447468