Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats
المؤلفون المشاركون
Suguna, Lonchin
Ponrasu, Thangavel
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aim of this work was to find out the effects of Annona squamosa on the formation of glycosaminoglycans and collagen during wound healing in normal and diabetic rats.
Diabetes induced rats were segregated into 4 groups, each containing six animals.
Groups I and III served as the normal and diabetic control while groups II and IV served as normal and diabetic treated.
The animals were treated with 200 μL of Annona squamosa extract topically.
The granulation tissues formed were removed on the 8th day and the amount of glycosaminoglycans (GAGs) and collagen formed was evaluated by sequential extraction and SDSPAGE, respectively.
Histological evaluation was also carried out using Masson's trichrome stain.
In vitro wound healing efficacy of A.
squamosa in human dermal fibroblast culture (HDF) was also carried out.
The fibroblasts treated with varying concentrations of A.
squamosa were examined for proliferation and closure of the wound area and photographed.
A.
squamosa increased cellular proliferation in HDF culture.
The granulation tissues of treated wounds showed increased levels of glycosaminoglycans (P<0.05) and collagen which were also confirmed by histopathology.
The results strongly substantiate the beneficial effects of A.
squamosa on the formation of glycosaminoglycans and collagen during wound healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ponrasu, Thangavel& Suguna, Lonchin. 2014. Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-447496
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ponrasu, Thangavel& Suguna, Lonchin. Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-447496
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ponrasu, Thangavel& Suguna, Lonchin. Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-447496
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447496
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر