Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats
Joint Authors
Suguna, Lonchin
Ponrasu, Thangavel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this work was to find out the effects of Annona squamosa on the formation of glycosaminoglycans and collagen during wound healing in normal and diabetic rats.
Diabetes induced rats were segregated into 4 groups, each containing six animals.
Groups I and III served as the normal and diabetic control while groups II and IV served as normal and diabetic treated.
The animals were treated with 200 μL of Annona squamosa extract topically.
The granulation tissues formed were removed on the 8th day and the amount of glycosaminoglycans (GAGs) and collagen formed was evaluated by sequential extraction and SDSPAGE, respectively.
Histological evaluation was also carried out using Masson's trichrome stain.
In vitro wound healing efficacy of A.
squamosa in human dermal fibroblast culture (HDF) was also carried out.
The fibroblasts treated with varying concentrations of A.
squamosa were examined for proliferation and closure of the wound area and photographed.
A.
squamosa increased cellular proliferation in HDF culture.
The granulation tissues of treated wounds showed increased levels of glycosaminoglycans (P<0.05) and collagen which were also confirmed by histopathology.
The results strongly substantiate the beneficial effects of A.
squamosa on the formation of glycosaminoglycans and collagen during wound healing.
American Psychological Association (APA)
Ponrasu, Thangavel& Suguna, Lonchin. 2014. Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-447496
Modern Language Association (MLA)
Ponrasu, Thangavel& Suguna, Lonchin. Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-447496
American Medical Association (AMA)
Ponrasu, Thangavel& Suguna, Lonchin. Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-447496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447496