Quantitative Measurements in 3-Dimensional Datasets of Mouse Lymph Nodes Resolve Organ-Wide Functional Dependencies
المؤلفون المشاركون
Sharpe, James
Mayer, Jürgen
Ozga, Aleksandra J.
Swoger, Jim
Stein, Jens V.
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Deep tissue imaging has become state of the art in biology, but now the problem is to quantify spatial information in a global, organ-wide context.
Although access to the raw data is no longer a limitation, the computational tools to extract biologically useful information out of these large data sets is still catching up.
In many cases, to understand the mechanism behind a biological process, where molecules or cells interact with each other, it is mandatory to know their mutual positions.
We illustrate this principle here with the immune system.
Although the general functions of lymph nodes as immune sentinels are well described, many cellular and molecular details governing the interactions of lymphocytes and dendritic cells remain unclear to date and prevent an in-depth mechanistic understanding of the immune system.
We imaged ex vivo lymph nodes isolated from both wild-type and transgenic mice lacking key factors for dendritic cell positioning and used software written in MATLAB to determine the spatial distances between the dendritic cells and the internal high endothelial vascular network.
This allowed us to quantify the spatial localization of the dendritic cells in the lymph node, which is a critical parameter determining the effectiveness of an adaptive immune response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mayer, Jürgen& Swoger, Jim& Ozga, Aleksandra J.& Stein, Jens V.& Sharpe, James. 2012. Quantitative Measurements in 3-Dimensional Datasets of Mouse Lymph Nodes Resolve Organ-Wide Functional Dependencies. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-447903
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mayer, Jürgen…[et al.]. Quantitative Measurements in 3-Dimensional Datasets of Mouse Lymph Nodes Resolve Organ-Wide Functional Dependencies. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-447903
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mayer, Jürgen& Swoger, Jim& Ozga, Aleksandra J.& Stein, Jens V.& Sharpe, James. Quantitative Measurements in 3-Dimensional Datasets of Mouse Lymph Nodes Resolve Organ-Wide Functional Dependencies. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-447903
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447903
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر