Expression of miRNAs in Papillary Thyroid Carcinomas Is Associated with BRAF Mutation and Clinicopathological Features in Chinese Patients
المؤلفون المشاركون
Wang, Fen
Sun, Yun
Liu, Yujie
Liu, Yuanyuan
Yu, Shuang
Xiao, Haipeng
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) dysregulation has been shown to play a critical regulatory role in papillary thyroid carcinomas (PTCs).
BRAF mutation is associated with poor clinicopathological outcomes in PTC.
In order to identify a possible association between dysregulated miRNA expression and BRAF mutation as well as clinicopathological features in Chinese patients with PTC, we examined the expression levels of five reported dysregulated miRNAs (miRNA-221, miRNA-222, miRNA-146b, miRNA-181, and miRNA-21) and determined BRAF mutation status in 52 patients with PTC and 52 patients with benign thyroid nodules (BTNs).
The expression levels of all five miRNAs were significantly increased in PTC when compared to BTN.
The BRAF mutation occurred more frequently in PTC cases with advanced TNM stage.
Importantly, miRNA-221, miRNA-222, miRNA-146b, and miRNA-181 expression levels were significantly higher in PTC patients with BRAF mutation.
In addition, enhanced expression of miRNA-221 and miRNA-222 was found in patients with cervical lymph node metastasis and advanced TNM stage.
Increased expression of miRNA-221 and miR-181 was evidenced in patients with larger tumors.
These findings showed a potential role of this distinct profile of miRNAs in differentiating PTC from BTN.
BRAF mutation might regulate or interact with miRNA in the pathogenesis and progression of PTC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Yun& Yu, Shuang& Liu, Yuanyuan& Wang, Fen& Liu, Yujie& Xiao, Haipeng. 2013. Expression of miRNAs in Papillary Thyroid Carcinomas Is Associated with BRAF Mutation and Clinicopathological Features in Chinese Patients. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-447937
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Yun…[et al.]. Expression of miRNAs in Papillary Thyroid Carcinomas Is Associated with BRAF Mutation and Clinicopathological Features in Chinese Patients. International Journal of Endocrinology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-447937
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Yun& Yu, Shuang& Liu, Yuanyuan& Wang, Fen& Liu, Yujie& Xiao, Haipeng. Expression of miRNAs in Papillary Thyroid Carcinomas Is Associated with BRAF Mutation and Clinicopathological Features in Chinese Patients. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-447937
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-447937
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر