Expression of miRNAs in Papillary Thyroid Carcinomas Is Associated with BRAF Mutation and Clinicopathological Features in Chinese Patients
Joint Authors
Wang, Fen
Sun, Yun
Liu, Yujie
Liu, Yuanyuan
Yu, Shuang
Xiao, Haipeng
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
MicroRNAs (miRNAs) dysregulation has been shown to play a critical regulatory role in papillary thyroid carcinomas (PTCs).
BRAF mutation is associated with poor clinicopathological outcomes in PTC.
In order to identify a possible association between dysregulated miRNA expression and BRAF mutation as well as clinicopathological features in Chinese patients with PTC, we examined the expression levels of five reported dysregulated miRNAs (miRNA-221, miRNA-222, miRNA-146b, miRNA-181, and miRNA-21) and determined BRAF mutation status in 52 patients with PTC and 52 patients with benign thyroid nodules (BTNs).
The expression levels of all five miRNAs were significantly increased in PTC when compared to BTN.
The BRAF mutation occurred more frequently in PTC cases with advanced TNM stage.
Importantly, miRNA-221, miRNA-222, miRNA-146b, and miRNA-181 expression levels were significantly higher in PTC patients with BRAF mutation.
In addition, enhanced expression of miRNA-221 and miRNA-222 was found in patients with cervical lymph node metastasis and advanced TNM stage.
Increased expression of miRNA-221 and miR-181 was evidenced in patients with larger tumors.
These findings showed a potential role of this distinct profile of miRNAs in differentiating PTC from BTN.
BRAF mutation might regulate or interact with miRNA in the pathogenesis and progression of PTC.
American Psychological Association (APA)
Sun, Yun& Yu, Shuang& Liu, Yuanyuan& Wang, Fen& Liu, Yujie& Xiao, Haipeng. 2013. Expression of miRNAs in Papillary Thyroid Carcinomas Is Associated with BRAF Mutation and Clinicopathological Features in Chinese Patients. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-447937
Modern Language Association (MLA)
Sun, Yun…[et al.]. Expression of miRNAs in Papillary Thyroid Carcinomas Is Associated with BRAF Mutation and Clinicopathological Features in Chinese Patients. International Journal of Endocrinology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-447937
American Medical Association (AMA)
Sun, Yun& Yu, Shuang& Liu, Yuanyuan& Wang, Fen& Liu, Yujie& Xiao, Haipeng. Expression of miRNAs in Papillary Thyroid Carcinomas Is Associated with BRAF Mutation and Clinicopathological Features in Chinese Patients. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-447937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-447937