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A Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in Yeast
المؤلفون المشاركون
Lone, Museer A.
Jablonowski, Daniel
Schneiter, Roger
Schaffrath, Raffael
Woodacre, Alexandra
Giorgini, Flaviano
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Ceramide is a building block for complex sphingolipids in the plasma membrane, but it also plays a significant role in secondary signalling pathways regulating cell proliferation and apoptosis in response to stress.
Ceramide activated protein phosphatase activity has been previously observed in association with the Sit4 protein phosphatase.
Here we find that sit4Δ mutants have decreased ceramide levels and display resistance to exogenous ceramides and phytosphingosine.
Mutants lacking SIT4 or KTI12 display a shift towards nonhydroxylated forms of long chain bases and sphingolipids, suggesting regulation of hydroxylase (SUR2) or ceramide synthase by Sit4p.
We have identified novel subunits of the Sit4 complex and have also shown that known Sit4 regulatory subunits—SAP proteins—are not involved in the ceramide response.
This is the first observation of separation of function between Sit4 and SAP proteins.
We also find that the Sit4p target Elongator is not involved in the ceramide response but that cells deficient in Kti12p—an accessory protein with an undefined regulatory role—have similar ceramide phenotypes to sit4Δ mutants.
Therefore, Kti12p may play a similar secondary role in the ceramide response.
This evidence points to a novel Sit4-dependent regulatory mechanism in response to ceramide stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Woodacre, Alexandra& Lone, Museer A.& Jablonowski, Daniel& Schneiter, Roger& Giorgini, Flaviano& Schaffrath, Raffael. 2013. A Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in Yeast. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-448019
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Woodacre, Alexandra…[et al.]. A Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in Yeast. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-448019
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Woodacre, Alexandra& Lone, Museer A.& Jablonowski, Daniel& Schneiter, Roger& Giorgini, Flaviano& Schaffrath, Raffael. A Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in Yeast. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-448019
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448019
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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