Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice
المؤلفون المشاركون
Vlaar, Alexander P. J.
Schultz, Marcus J.
Roelofs, Joris J. T. H.
Levi, Marcel
Juffermans, Nicole P.
Choi, Goda
Wolthuis, Esther K.
المصدر
Critical Care Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Preventing tissue-factor-(TF-) mediated systemic coagulopathy improves outcome in models of sepsis.
Preventing TF-mediated pulmonary coagulopathy could attenuate ventilator-induced lung injury (VILI).
We investigated the effect of relative TF deficiency on pulmonary coagulopathy and inflammation in a murine model of VILI.
Heterozygous TF knockout (TF+/−) mice and their wild-type (TF+/+) littermates were sedated (controls) or sedated, tracheotomized, and mechanically ventilated with either low or high tidal volumes for 5 hours.
Mechanical ventilation resulted in pulmonary coagulopathy and inflammation, with more injury after mechanical ventilation with higher tidal volumes.
Compared with TF+/+ mice, TF+/− mice demonstrated significantly lower pulmonary thrombin-antithrombin complex levels in both ventilation groups.
There were, however, no differences in lung wet-to-dry ratio, BALF total protein levels, neutrophil influx, and lung histopathology scores between TF+/− and TF+/+ mice.
Notably, pulmonary levels of cytokines were significantly higher in TF+/− as compared to TF+/+ mice.
Systemic levels of cytokines were not altered by the relative absence of TF.
TF deficiency is associated with decreased pulmonary coagulation independent of the ventilation strategy.
However, relative TF deficiency does not reduce VILI and actually results in higher pulmonary levels of inflammatory mediators.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wolthuis, Esther K.& Vlaar, Alexander P. J.& Choi, Goda& Roelofs, Joris J. T. H.& Levi, Marcel& Juffermans, Nicole P.…[et al.]. 2011. Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wolthuis, Esther K.…[et al.]. Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. Critical Care Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-448072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wolthuis, Esther K.& Vlaar, Alexander P. J.& Choi, Goda& Roelofs, Joris J. T. H.& Levi, Marcel& Juffermans, Nicole P.…[et al.]. Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. Critical Care Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر