Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice
Joint Authors
Vlaar, Alexander P. J.
Schultz, Marcus J.
Roelofs, Joris J. T. H.
Levi, Marcel
Juffermans, Nicole P.
Choi, Goda
Wolthuis, Esther K.
Source
Critical Care Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Preventing tissue-factor-(TF-) mediated systemic coagulopathy improves outcome in models of sepsis.
Preventing TF-mediated pulmonary coagulopathy could attenuate ventilator-induced lung injury (VILI).
We investigated the effect of relative TF deficiency on pulmonary coagulopathy and inflammation in a murine model of VILI.
Heterozygous TF knockout (TF+/−) mice and their wild-type (TF+/+) littermates were sedated (controls) or sedated, tracheotomized, and mechanically ventilated with either low or high tidal volumes for 5 hours.
Mechanical ventilation resulted in pulmonary coagulopathy and inflammation, with more injury after mechanical ventilation with higher tidal volumes.
Compared with TF+/+ mice, TF+/− mice demonstrated significantly lower pulmonary thrombin-antithrombin complex levels in both ventilation groups.
There were, however, no differences in lung wet-to-dry ratio, BALF total protein levels, neutrophil influx, and lung histopathology scores between TF+/− and TF+/+ mice.
Notably, pulmonary levels of cytokines were significantly higher in TF+/− as compared to TF+/+ mice.
Systemic levels of cytokines were not altered by the relative absence of TF.
TF deficiency is associated with decreased pulmonary coagulation independent of the ventilation strategy.
However, relative TF deficiency does not reduce VILI and actually results in higher pulmonary levels of inflammatory mediators.
American Psychological Association (APA)
Wolthuis, Esther K.& Vlaar, Alexander P. J.& Choi, Goda& Roelofs, Joris J. T. H.& Levi, Marcel& Juffermans, Nicole P.…[et al.]. 2011. Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448072
Modern Language Association (MLA)
Wolthuis, Esther K.…[et al.]. Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. Critical Care Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-448072
American Medical Association (AMA)
Wolthuis, Esther K.& Vlaar, Alexander P. J.& Choi, Goda& Roelofs, Joris J. T. H.& Levi, Marcel& Juffermans, Nicole P.…[et al.]. Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. Critical Care Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448072