Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model
المؤلفون المشاركون
Furukawa, Hiroshi
Minagawa, Tomohiro
Yamamoto, Yuhei
Tabata, Yasuhiko
Yamao, Takeshi
Oyama, Akihiko
المصدر
International Journal of Biomaterials
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Autologous bone grafts remain the gold standard for the treatment of congenital craniofacial disorders; however, there are potential problems including donor site morbidity and limitations to the amount of bone that can be harvested.
Recent studies suggest that granulocyte colony-stimulating factor (G-CSF) promotes fracture healing or osteogenesis.
The purpose of the present study was to investigate whether topically applied G-CSF can stimulate the osteoconductive properties of beta-tricalcium phosphate (β-TCP) in a rat calvarial defect model.
A total of 27 calvarial defects 5 mm in diameter were randomly divided into nine groups, which were treated with various combinations of a β-TCP disc and G-CSF in solution form or controlled release system using gelatin hydrogel.
Histologic and histomorphometric analyses were performed at eight weeks postoperatively.
The controlled release of low-dose (1 μg and 5 μg) G-CSF significantly enhanced new bone formation when combined with a β-TCP disc.
Moreover, administration of 5 μg G-CSF using a controlled release system significantly promoted the biodegradable properties of β-TCP.
In conclusion, the controlled release of 5 μg G-CSF significantly enhanced the osteoconductive and biodegradable properties of β-TCP.
The combination of G-CSF slow-release and β-TCP is a novel and promising approach for treating pediatric craniofacial bone defects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Minagawa, Tomohiro& Tabata, Yasuhiko& Oyama, Akihiko& Furukawa, Hiroshi& Yamao, Takeshi& Yamamoto, Yuhei. 2014. Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model. International Journal of Biomaterials،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-448366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Minagawa, Tomohiro…[et al.]. Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model. International Journal of Biomaterials No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-448366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Minagawa, Tomohiro& Tabata, Yasuhiko& Oyama, Akihiko& Furukawa, Hiroshi& Yamao, Takeshi& Yamamoto, Yuhei. Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model. International Journal of Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-448366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر