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Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model
Joint Authors
Furukawa, Hiroshi
Minagawa, Tomohiro
Yamamoto, Yuhei
Tabata, Yasuhiko
Yamao, Takeshi
Oyama, Akihiko
Source
International Journal of Biomaterials
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Autologous bone grafts remain the gold standard for the treatment of congenital craniofacial disorders; however, there are potential problems including donor site morbidity and limitations to the amount of bone that can be harvested.
Recent studies suggest that granulocyte colony-stimulating factor (G-CSF) promotes fracture healing or osteogenesis.
The purpose of the present study was to investigate whether topically applied G-CSF can stimulate the osteoconductive properties of beta-tricalcium phosphate (β-TCP) in a rat calvarial defect model.
A total of 27 calvarial defects 5 mm in diameter were randomly divided into nine groups, which were treated with various combinations of a β-TCP disc and G-CSF in solution form or controlled release system using gelatin hydrogel.
Histologic and histomorphometric analyses were performed at eight weeks postoperatively.
The controlled release of low-dose (1 μg and 5 μg) G-CSF significantly enhanced new bone formation when combined with a β-TCP disc.
Moreover, administration of 5 μg G-CSF using a controlled release system significantly promoted the biodegradable properties of β-TCP.
In conclusion, the controlled release of 5 μg G-CSF significantly enhanced the osteoconductive and biodegradable properties of β-TCP.
The combination of G-CSF slow-release and β-TCP is a novel and promising approach for treating pediatric craniofacial bone defects.
American Psychological Association (APA)
Minagawa, Tomohiro& Tabata, Yasuhiko& Oyama, Akihiko& Furukawa, Hiroshi& Yamao, Takeshi& Yamamoto, Yuhei. 2014. Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model. International Journal of Biomaterials،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-448366
Modern Language Association (MLA)
Minagawa, Tomohiro…[et al.]. Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model. International Journal of Biomaterials No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-448366
American Medical Association (AMA)
Minagawa, Tomohiro& Tabata, Yasuhiko& Oyama, Akihiko& Furukawa, Hiroshi& Yamao, Takeshi& Yamamoto, Yuhei. Controlled Release of Granulocyte Colony-Stimulating Factor Enhances Osteoconductive and Biodegradable Properties of Beta-Tricalcium Phosphate in a Rat Calvarial Defect Model. International Journal of Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-448366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448366