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Impacts of Membrane Biophysics in Alzheimer's Disease : From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes
المؤلفون المشاركون
Askarova, Sholpan
Yang, Xiaoguang
Lee, James C.-M.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer's disease (AD), are strongly associated with its ability to interact with membranes of neurons and other cerebral cells.
Aβ is derived from amyloidogenic cleavage of amyloid precursor protein (AβPP) by β- and γ-secretase.
In the nonamyloidogenic pathway, AβPP is cleaved by α-secretases.
These two pathways compete with each other, and enhancing the non-amyloidogenic pathway has been suggested as a potential pharmacological approach for the treatment of AD.
Since AβPP, α-, β-, and γ-secretases are membrane-associated proteins, AβPP processing and Aβ production can be affected by the membrane composition and properties.
There is evidence that membrane composition and properties, in turn, play a critical role in Aβ cytotoxicity associated with its conformational changes and aggregation into oligomers and fibrils.
Understanding the mechanisms leading to changes in a membrane's biophysical properties and how they affect AβPP processing and Aβ toxicity should prove to provide new therapeutic strategies for prevention and treatment of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Askarova, Sholpan& Yang, Xiaoguang& Lee, James C.-M.. 2011. Impacts of Membrane Biophysics in Alzheimer's Disease : From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-448427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Askarova, Sholpan…[et al.]. Impacts of Membrane Biophysics in Alzheimer's Disease : From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-448427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Askarova, Sholpan& Yang, Xiaoguang& Lee, James C.-M.. Impacts of Membrane Biophysics in Alzheimer's Disease : From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-448427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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