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Impacts of Membrane Biophysics in Alzheimer's Disease : From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes
Joint Authors
Askarova, Sholpan
Yang, Xiaoguang
Lee, James C.-M.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer's disease (AD), are strongly associated with its ability to interact with membranes of neurons and other cerebral cells.
Aβ is derived from amyloidogenic cleavage of amyloid precursor protein (AβPP) by β- and γ-secretase.
In the nonamyloidogenic pathway, AβPP is cleaved by α-secretases.
These two pathways compete with each other, and enhancing the non-amyloidogenic pathway has been suggested as a potential pharmacological approach for the treatment of AD.
Since AβPP, α-, β-, and γ-secretases are membrane-associated proteins, AβPP processing and Aβ production can be affected by the membrane composition and properties.
There is evidence that membrane composition and properties, in turn, play a critical role in Aβ cytotoxicity associated with its conformational changes and aggregation into oligomers and fibrils.
Understanding the mechanisms leading to changes in a membrane's biophysical properties and how they affect AβPP processing and Aβ toxicity should prove to provide new therapeutic strategies for prevention and treatment of AD.
American Psychological Association (APA)
Askarova, Sholpan& Yang, Xiaoguang& Lee, James C.-M.. 2011. Impacts of Membrane Biophysics in Alzheimer's Disease : From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-448427
Modern Language Association (MLA)
Askarova, Sholpan…[et al.]. Impacts of Membrane Biophysics in Alzheimer's Disease : From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-448427
American Medical Association (AMA)
Askarova, Sholpan& Yang, Xiaoguang& Lee, James C.-M.. Impacts of Membrane Biophysics in Alzheimer's Disease : From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-448427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448427