Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models
المؤلفون المشاركون
Carmona, Manuel
Alonso, Gonzalo L.
Scarsella, Luca
Lenzi, Andrea
Festuccia, Claudio
Mancini, Andrea
Jannini, Emmanuele A.
Di Cesare, Ernesto
Tatone, Carla
Llorens, Silvia
Gravina, Giovanni Luca
D’Alessandro, Anna M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Crocus sativus L.
extracts (saffron) are rich in carotenoids.
Preclinical studies have shown that dietary intake of carotenoids has antitumor effects suggesting their potential preventive and/or therapeutic roles.
We have recently reported that saffron (SE) and crocin (CR) exhibit anticancer activity by promoting cell cycle arrest in prostate cancer (PCa) cells.
It has also been demonstrated that crocetin esters are produced after SE gastrointestinal digestion by CR hydrolysis.
The aim of the present report was to investigate if SE, crocetin (CCT), and CR affected in vivo tumor growth of two aggressive PCa cell lines (PC3 and 22rv1) which were xenografted in male nude mice treated by oral gavage with SE, CR, and CCT.
We demonstrated that the antitumor effects of CCT were higher when compared to CR and SE and treatments reverted the epithelial-mesenchymal transdifferentiation (EMT) as attested by the significant reduction of N-cadherin and beta-catenin expression and the increased expression of E-cadherin.
Additionally, SE, CR, and CCT inhibited PCa cell invasion and migration through the downmodulation of metalloproteinase and urokinase expression/activity suggesting that these agents may affect metastatic processes.
Our findings suggest that CR and CCT may be dietary phytochemicals with potential antitumor effects in biologically aggressive PCa cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Festuccia, Claudio& Mancini, Andrea& Gravina, Giovanni Luca& Scarsella, Luca& Llorens, Silvia& Alonso, Gonzalo L.…[et al.]. 2014. Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-448440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Festuccia, Claudio…[et al.]. Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-448440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Festuccia, Claudio& Mancini, Andrea& Gravina, Giovanni Luca& Scarsella, Luca& Llorens, Silvia& Alonso, Gonzalo L.…[et al.]. Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-448440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر