![](/images/graphics-bg.png)
Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models
Joint Authors
Carmona, Manuel
Alonso, Gonzalo L.
Scarsella, Luca
Lenzi, Andrea
Festuccia, Claudio
Mancini, Andrea
Jannini, Emmanuele A.
Di Cesare, Ernesto
Tatone, Carla
Llorens, Silvia
Gravina, Giovanni Luca
D’Alessandro, Anna M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Crocus sativus L.
extracts (saffron) are rich in carotenoids.
Preclinical studies have shown that dietary intake of carotenoids has antitumor effects suggesting their potential preventive and/or therapeutic roles.
We have recently reported that saffron (SE) and crocin (CR) exhibit anticancer activity by promoting cell cycle arrest in prostate cancer (PCa) cells.
It has also been demonstrated that crocetin esters are produced after SE gastrointestinal digestion by CR hydrolysis.
The aim of the present report was to investigate if SE, crocetin (CCT), and CR affected in vivo tumor growth of two aggressive PCa cell lines (PC3 and 22rv1) which were xenografted in male nude mice treated by oral gavage with SE, CR, and CCT.
We demonstrated that the antitumor effects of CCT were higher when compared to CR and SE and treatments reverted the epithelial-mesenchymal transdifferentiation (EMT) as attested by the significant reduction of N-cadherin and beta-catenin expression and the increased expression of E-cadherin.
Additionally, SE, CR, and CCT inhibited PCa cell invasion and migration through the downmodulation of metalloproteinase and urokinase expression/activity suggesting that these agents may affect metastatic processes.
Our findings suggest that CR and CCT may be dietary phytochemicals with potential antitumor effects in biologically aggressive PCa cells.
American Psychological Association (APA)
Festuccia, Claudio& Mancini, Andrea& Gravina, Giovanni Luca& Scarsella, Luca& Llorens, Silvia& Alonso, Gonzalo L.…[et al.]. 2014. Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-448440
Modern Language Association (MLA)
Festuccia, Claudio…[et al.]. Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-448440
American Medical Association (AMA)
Festuccia, Claudio& Mancini, Andrea& Gravina, Giovanni Luca& Scarsella, Luca& Llorens, Silvia& Alonso, Gonzalo L.…[et al.]. Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-448440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448440