Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol
المؤلفون المشاركون
Veerman, Anjo J. P.
Sutaryo,
Purwanto, Ignatius
Supriyadi, Eddy
Cloos, Jacqueline
vd Ven, Peter M.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The frequency of acute lymphoblastic leukemia (ALL) patients expressing myeloid antigens on their ALL cells varies between 5 and 36% in several different studies.
The clinical relevance of myeloid antigen expression in childhood ALL is controversial.
In Indonesian patients, no data were present.
Therefore, in Yogyakarta, Indonesia, we analyzed 239 ALL patients who were immunophenotyped including myeloid markers (CD13, CD33, CD117, and/or cMPO).
Myeloid antigen expression was found in 25% of patients.
Expression of myeloid antigen in B-lineage leukemia was 27%, and in T-lineage leukemia, it was 18% (P=0.15).
No association was found between myeloid antigen expression and clinical or biological features.
In the whole cohort of patients we did not find a significant association between myeloid antigen expression and survival, although leukemia-free survival at 3 years was higher in the myeloid-negative patients (73% ± 6%) compared to myeloid-positive patients (67% ± 8%).
Interestingly, in T-ALL patients, expression of myeloid antigens was an independent adverse prognostic factor (hazard ratio: 3.26, 95% CI: 1.06–9.98, P=0.04).
Kaplan-Meier analysis for event-free survival was also significant (log rank P=0.03) in this subgroup.
In conclusion, in the Indonesian ALL population, in particular, myeloid antigen-expressing T-ALL patients had a higher chance of having induction failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Supriyadi, Eddy& Veerman, Anjo J. P.& Sutaryo, & Purwanto, Ignatius& vd Ven, Peter M.& Cloos, Jacqueline. 2012. Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol. Journal of Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448452
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Supriyadi, Eddy…[et al.]. Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol. Journal of Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-448452
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Supriyadi, Eddy& Veerman, Anjo J. P.& Sutaryo, & Purwanto, Ignatius& vd Ven, Peter M.& Cloos, Jacqueline. Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448452
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448452
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر