Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol
Joint Authors
Veerman, Anjo J. P.
Sutaryo,
Purwanto, Ignatius
Supriyadi, Eddy
Cloos, Jacqueline
vd Ven, Peter M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The frequency of acute lymphoblastic leukemia (ALL) patients expressing myeloid antigens on their ALL cells varies between 5 and 36% in several different studies.
The clinical relevance of myeloid antigen expression in childhood ALL is controversial.
In Indonesian patients, no data were present.
Therefore, in Yogyakarta, Indonesia, we analyzed 239 ALL patients who were immunophenotyped including myeloid markers (CD13, CD33, CD117, and/or cMPO).
Myeloid antigen expression was found in 25% of patients.
Expression of myeloid antigen in B-lineage leukemia was 27%, and in T-lineage leukemia, it was 18% (P=0.15).
No association was found between myeloid antigen expression and clinical or biological features.
In the whole cohort of patients we did not find a significant association between myeloid antigen expression and survival, although leukemia-free survival at 3 years was higher in the myeloid-negative patients (73% ± 6%) compared to myeloid-positive patients (67% ± 8%).
Interestingly, in T-ALL patients, expression of myeloid antigens was an independent adverse prognostic factor (hazard ratio: 3.26, 95% CI: 1.06–9.98, P=0.04).
Kaplan-Meier analysis for event-free survival was also significant (log rank P=0.03) in this subgroup.
In conclusion, in the Indonesian ALL population, in particular, myeloid antigen-expressing T-ALL patients had a higher chance of having induction failure.
American Psychological Association (APA)
Supriyadi, Eddy& Veerman, Anjo J. P.& Sutaryo, & Purwanto, Ignatius& vd Ven, Peter M.& Cloos, Jacqueline. 2012. Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol. Journal of Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448452
Modern Language Association (MLA)
Supriyadi, Eddy…[et al.]. Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol. Journal of Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-448452
American Medical Association (AMA)
Supriyadi, Eddy& Veerman, Anjo J. P.& Sutaryo, & Purwanto, Ignatius& vd Ven, Peter M.& Cloos, Jacqueline. Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448452