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Changing Global Trends in Seizure Outcomes Following Resective Surgery for Tuberous Sclerosis in Children with Medically Intractable Epilepsy
المؤلفون المشاركون
Rutka, James T.
Carter Snead, O.
Fallah, Aria
Ibrahim, George M.
المصدر
Epilepsy Research and Treatment
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
Tuberous sclerosis (TS) is the leading cause of genetic epilepsy worldwide.
Here, we evaluate changes in seizure outcomes following resective epilepsy surgery in children with TS over time.
Methods.
A systematic review of the literature was performed to identify studies reporting seizure outcomes following resective epilepsy surgery in children with TS.
Using an individual participant meta-analysis approach, seizure outcomes and associated covariates were combined.
Multivariate logistic regression was used to determine significant associations between seizure outcomes and time of surgery.
Results.
Twenty studies from 1966 to present, yielding 186 participants, met the inclusion criteria for the study.
On univariate analysis, there was a significant improvement in seizure outcomes in children who underwent resective epilepsy surgery within the last 15 years compared to older cohorts (chi-square 4.1; P=0.043).
On multivariate analysis, adjusting for length of followup, this trend was not significant (OR 0.52; 95% CI 0.23–1.17; P=0.11).
In the last 15 years, a greater proportion of younger children also underwent resective surgery compared to older cohorts (OR 0.93; 95% CI 0.89–0.97; P<0.01).
Conclusions.
A trend towards improved seizure outcomes following resective surgery for TS was observed from 1966 to present on multivariate analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, George M.& Fallah, Aria& Carter Snead, O.& Rutka, James T.. 2012. Changing Global Trends in Seizure Outcomes Following Resective Surgery for Tuberous Sclerosis in Children with Medically Intractable Epilepsy. Epilepsy Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-448478
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, George M.…[et al.]. Changing Global Trends in Seizure Outcomes Following Resective Surgery for Tuberous Sclerosis in Children with Medically Intractable Epilepsy. Epilepsy Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-448478
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, George M.& Fallah, Aria& Carter Snead, O.& Rutka, James T.. Changing Global Trends in Seizure Outcomes Following Resective Surgery for Tuberous Sclerosis in Children with Medically Intractable Epilepsy. Epilepsy Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-448478
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448478
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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