![](/images/graphics-bg.png)
Changing Global Trends in Seizure Outcomes Following Resective Surgery for Tuberous Sclerosis in Children with Medically Intractable Epilepsy
Joint Authors
Rutka, James T.
Carter Snead, O.
Fallah, Aria
Ibrahim, George M.
Source
Epilepsy Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Tuberous sclerosis (TS) is the leading cause of genetic epilepsy worldwide.
Here, we evaluate changes in seizure outcomes following resective epilepsy surgery in children with TS over time.
Methods.
A systematic review of the literature was performed to identify studies reporting seizure outcomes following resective epilepsy surgery in children with TS.
Using an individual participant meta-analysis approach, seizure outcomes and associated covariates were combined.
Multivariate logistic regression was used to determine significant associations between seizure outcomes and time of surgery.
Results.
Twenty studies from 1966 to present, yielding 186 participants, met the inclusion criteria for the study.
On univariate analysis, there was a significant improvement in seizure outcomes in children who underwent resective epilepsy surgery within the last 15 years compared to older cohorts (chi-square 4.1; P=0.043).
On multivariate analysis, adjusting for length of followup, this trend was not significant (OR 0.52; 95% CI 0.23–1.17; P=0.11).
In the last 15 years, a greater proportion of younger children also underwent resective surgery compared to older cohorts (OR 0.93; 95% CI 0.89–0.97; P<0.01).
Conclusions.
A trend towards improved seizure outcomes following resective surgery for TS was observed from 1966 to present on multivariate analysis.
American Psychological Association (APA)
Ibrahim, George M.& Fallah, Aria& Carter Snead, O.& Rutka, James T.. 2012. Changing Global Trends in Seizure Outcomes Following Resective Surgery for Tuberous Sclerosis in Children with Medically Intractable Epilepsy. Epilepsy Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-448478
Modern Language Association (MLA)
Ibrahim, George M.…[et al.]. Changing Global Trends in Seizure Outcomes Following Resective Surgery for Tuberous Sclerosis in Children with Medically Intractable Epilepsy. Epilepsy Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-448478
American Medical Association (AMA)
Ibrahim, George M.& Fallah, Aria& Carter Snead, O.& Rutka, James T.. Changing Global Trends in Seizure Outcomes Following Resective Surgery for Tuberous Sclerosis in Children with Medically Intractable Epilepsy. Epilepsy Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-448478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448478