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The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus : Comparison of Neuropsychiatric and Nonneuropsychiatric Groups
المؤلفون المشاركون
Kung, Chia-Te
Chang, Ya-Ting
Chiang, Yi-Fang
Tsai, Nai-Wen
Chiu, Wen-Chan
Cheng, Ben-Chung
Lu, Cheng-Hsien
Lin, Wei-Che
Chen, Chung-Jen
Cheng, Tien-Tsai
Su, Yu-Jih
Chang, Wen-Neng
Huang, Chih-Cheng
Su, Chih-Min
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Antioxidative capacity plays an important role in the severity of systemic lupus erythematosus (SLE), which is characterized by autoantibodies.
This study aimed to determine the relationship among autoantibody titers, antioxidative stress reserve, and severity of SLE.
Methods.
The autoantibody titers, clinical markers, antioxidant enzyme levels, and disease activity index (SLEDAI-2k) of 32 SLE patients and 16 healthy controls were compared.
We also compared both the neuropsychiatric (NPSLE) and nonneuropsychiatric (non-NPSLE) groups.
Results.
Superoxide dismutase in red blood cells was significantly lower in the SLE than in the control group.
CRP levels are significant higher in SLE patients than in control group (P=0.034).
Among the autoantibodies, anti-U1RNP P=0.008, a-Sm P=0.027, and anti-ribosomal p P=0.028 significantly negatively correlated with glutathione levels.
There has no significant correlation between SLE disease activity indexes (SLEDAI) and levels of C3, C4, and antioxidant enzymes.
Conclusions.
Erythrocyte superoxide dismutase is significantly lower in both NPSLE and non-NPSLE groups.
SLE patients have both higher CRP and autoantibodies level and decreased superoxide dismutase level than the healthy control group.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Yu-Jih& Cheng, Tien-Tsai& Chen, Chung-Jen& Chiu, Wen-Chan& Chang, Wen-Neng& Tsai, Nai-Wen…[et al.]. 2014. The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus : Comparison of Neuropsychiatric and Nonneuropsychiatric Groups. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448638
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Yu-Jih…[et al.]. The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus : Comparison of Neuropsychiatric and Nonneuropsychiatric Groups. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-448638
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Yu-Jih& Cheng, Tien-Tsai& Chen, Chung-Jen& Chiu, Wen-Chan& Chang, Wen-Neng& Tsai, Nai-Wen…[et al.]. The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus : Comparison of Neuropsychiatric and Nonneuropsychiatric Groups. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448638
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448638
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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