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The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus : Comparison of Neuropsychiatric and Nonneuropsychiatric Groups
Joint Authors
Kung, Chia-Te
Chang, Ya-Ting
Chiang, Yi-Fang
Tsai, Nai-Wen
Chiu, Wen-Chan
Cheng, Ben-Chung
Lu, Cheng-Hsien
Lin, Wei-Che
Chen, Chung-Jen
Cheng, Tien-Tsai
Su, Yu-Jih
Chang, Wen-Neng
Huang, Chih-Cheng
Su, Chih-Min
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Antioxidative capacity plays an important role in the severity of systemic lupus erythematosus (SLE), which is characterized by autoantibodies.
This study aimed to determine the relationship among autoantibody titers, antioxidative stress reserve, and severity of SLE.
Methods.
The autoantibody titers, clinical markers, antioxidant enzyme levels, and disease activity index (SLEDAI-2k) of 32 SLE patients and 16 healthy controls were compared.
We also compared both the neuropsychiatric (NPSLE) and nonneuropsychiatric (non-NPSLE) groups.
Results.
Superoxide dismutase in red blood cells was significantly lower in the SLE than in the control group.
CRP levels are significant higher in SLE patients than in control group (P=0.034).
Among the autoantibodies, anti-U1RNP P=0.008, a-Sm P=0.027, and anti-ribosomal p P=0.028 significantly negatively correlated with glutathione levels.
There has no significant correlation between SLE disease activity indexes (SLEDAI) and levels of C3, C4, and antioxidant enzymes.
Conclusions.
Erythrocyte superoxide dismutase is significantly lower in both NPSLE and non-NPSLE groups.
SLE patients have both higher CRP and autoantibodies level and decreased superoxide dismutase level than the healthy control group.
American Psychological Association (APA)
Su, Yu-Jih& Cheng, Tien-Tsai& Chen, Chung-Jen& Chiu, Wen-Chan& Chang, Wen-Neng& Tsai, Nai-Wen…[et al.]. 2014. The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus : Comparison of Neuropsychiatric and Nonneuropsychiatric Groups. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448638
Modern Language Association (MLA)
Su, Yu-Jih…[et al.]. The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus : Comparison of Neuropsychiatric and Nonneuropsychiatric Groups. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-448638
American Medical Association (AMA)
Su, Yu-Jih& Cheng, Tien-Tsai& Chen, Chung-Jen& Chiu, Wen-Chan& Chang, Wen-Neng& Tsai, Nai-Wen…[et al.]. The Association among Antioxidant Enzymes, Autoantibodies, and Disease Severity Score in Systemic Lupus Erythematosus : Comparison of Neuropsychiatric and Nonneuropsychiatric Groups. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448638